CACNA2D4
| Gene Symbol | CACNA2D4 |
|---|---|
| Entrez Gene | 93589 |
| Alt Symbol | RCD4 |
| Species | Human |
| Gene Type | protein-coding |
| Description | calcium channel, voltage-dependent, alpha 2/delta subunit 4 |
| Other Description | voltage-dependent calcium channel subunit alpha-2/delta-4|voltage-gated calcium channel alpha(2)delta-4 subunit|voltage-gated calcium channel subunit alpha-2/delta-4 |
| Swissprots | Q8IZS9 Q86XZ5 Q7Z3S7 Q7Z3S8 |
| Accessions | EAW88918 EAW88919 EAW88920 Q7Z3S7 AA001411 AF516695 AAN06672 AI160471 AK301234 BAG62806 AL137658 BC048288 AAH48288 BC150186 AAI50187 BI908421 BX457018 BX537436 CAD97678 BX537437 CAD97679 CA443847 EU832150 ACE87500 EU832243 ACE86813 XM_011521041 XP_011519343 XR_931529 XR_931530 XR_931531 NM_172364 NP_758952 NM_001005737 NM_001005766 |
| Function | The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. {ECO:0000269|PubMed:12181424}. |
| Subcellular Location | Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. |
| Tissue Specificity | Predominantly expressed in certain types of endocrine cells. Present in the Paneth cells of the small intestine. Also present in the erythroblasts in the fetal liver, in the cells of the zona reticularis of the adrenal gland and in the basophils of the pituitary. Present at low level in some brain regions such as the cerebellum (at protein level). {ECO:0000269|PubMed:12181424}. |
| Top Pathways | MAPK signaling pathway, Cardiac muscle contraction, Hypertrophic cardiomyopathy (HCM), Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy |
Cacna2d4 CRISPR/Cas9 KO Plasmid (h) - sc-413979 from Santa Cruz Biotechnology
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Cacna2d4 HDR Plasmid (h) - sc-413979-HDR from Santa Cruz Biotechnology
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Cacna2d4 Double Nickase Plasmid (h) - sc-413979-NIC from Santa Cruz Biotechnology
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Cacna2d4 Double Nickase Plasmid (h2) - sc-413979-NIC-2 from Santa Cruz Biotechnology
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Cacna2d4 CRISPR Activation Plasmid (h) - sc-413979-ACT from Santa Cruz Biotechnology
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Cacna2d4 CRISPR Activation Plasmid (h2) - sc-413979-ACT-2 from Santa Cruz Biotechnology
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Cacna2d4 Lentiviral Activation Particles (h) - sc-413979-LAC from Santa Cruz Biotechnology
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Cacna2d4 Lentiviral Activation Particles (h2) - sc-413979-LAC-2 from Santa Cruz Biotechnology
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Cacna2d4 siRNA (h) - sc-96027 from Santa Cruz Biotechnology
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Cacna2d4 shRNA Plasmid (h) - sc-96027-SH from Santa Cruz Biotechnology
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Cacna2d4 shRNA (h) Lentiviral Particles - sc-96027-V from Santa Cruz Biotechnology
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CACNA2D4 RNAi - H00093589-R02 from Novus Biologicals
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MISSION® esiRNA - EHU017261 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1132 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1132 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10178 from Sigma-Aldrich
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CACNA2D4 siRNA (Human) - CRJ4215 from Cohesion Biosciences
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CACNA2D4 RNAi - H00093589-R01 from Novus Biologicals
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CACNA2D4 RNAi - H00093589-R03 from Novus Biologicals
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CACNA2D4 - MBS8218678 from MyBioSource
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shRNA set against Human CACNA2D4 (NM_172364.4) - SHH253405 from Creative biogene
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shRNA set against Human CACNA2D4(NM_172364.4) - SHG131497 from Creative biogene
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Human CACNA2D4 siRNA - orb274716 from Biorbyt
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CACNA2D4 shRNA Plasmid (Human) - CHJ4215 from Cohesion Biosciences
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CACNA2D4 miRNA 3'UTR clone - MiUTR1H-01604 from Creative biogene
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