| Gene Symbol |
MAP3K7
|
| Entrez Gene |
6885
|
| Alt Symbol |
MEKK7, TAK1, TGF1a
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mitogen-activated protein kinase kinase kinase 7
|
| Other Description |
TGF-beta activated kinase 1|TGF-beta-activated kinase 1|transforming growth factor-beta-activated kinase 1
|
| Swissprots |
B2RE27 O43317 Q5TDT7 Q5TDN2 Q9NZ70 O43318 O43319 E1P523 Q5TDN3 Q9NTR3
|
| Accessions |
ABC40734 EAW48525 EAW48526 EAW48527 EAW48528 EAW48529 O43318 AB009356 BAA25025 AB009357 BAA25026 AB009358 BAA25027 AF218074 AAF27652 AI147171 AK055901 AK299268 BAG61290 AK315774 BAG38124 AL050393 CAB43687 AL520975 BC017715 AAH17715 BM172351 BT019654 AAV38460 BT019655 AAV38461 BX648277 XM_006715553 XP_006715616 NM_003188 NP_003179 NM_145331 NP_663304 NM_145332 NP_663305 NM_145333 NP_663306
|
| Function |
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs, c-jun N-terminal kinases (JNKs) and I-kappa-B kinase complex (IKK). Both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1), while nuclear
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:12242293}. Cell membrane {ECO:0000269|PubMed:12242293}; Peripheral membrane protein {ECO:0000269|PubMed:12242293}; Cytoplasmic side {ECO:0000269|PubMed:12242293}. Note=Although the majority of MAP3K7/TAK1 is found in the cytosol, when complexed with TAB1/MAP3K7IP1 and TAB2/MAP3K7IP2, it is also localized at the cell membrane.
|
| Tissue Specificity |
Isoform 1A is the most abundant in ovary, skeletal muscle, spleen and blood mononuclear cells. Isoform 1B is highly expressed in brain, kidney and small intestine. Isoform 1C is the major form in prostate. Isoform 1D is the less abundant form. {ECO:0000269|PubMed:11118615}.
|
| Top Pathways |
AMPK signaling pathway, Epstein-Barr virus infection, Herpes simplex infection, TNF signaling pathway, Wnt signaling pathway
|