Gene Symbol | DHX15 |
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Entrez Gene | 1665 |
Alt Symbol | DBP1, DDX15, HRH2, PRP43, PRPF43, PrPp43p |
Species | Human |
Gene Type | protein-coding |
Description | DEAH (Asp-Glu-Ala-His) box helicase 15 |
Other Description | ATP-dependent RNA helicase #46|DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 15|DEAD/H box-15|DEAH (Asp-Glu-Ala-His) box polypeptide 15|DEAH box protein 15|RNA helicase 2|putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 |
Swissprots | Q9NQT7 O43143 |
Accessions | EAW92814 EAW92815 EAW92816 EAW92817 EAW92818 EAW92819 EAW92820 EAW92821 O43143 AA771922 AB001636 BAA23987 AF279891 AAF90182 AK054614 AK055898 AK056726 AK303506 BAG64538 BC035974 AAH35974 BC047577 BU158645 XR_925314 NM_001358 NP_001349 |
Function | Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. {ECO:0000269|PubMed:19103666}. |
Subcellular Location | Nucleus. Nucleus, nucleolus. |
Tissue Specificity | Ubiquitous. |
Top Pathways | Spliceosome |
DDX15 CRISPR/Cas9 KO Plasmid (h) - sc-403959 from Santa Cruz Biotechnology
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DDX15 HDR Plasmid (h) - sc-403959-HDR from Santa Cruz Biotechnology
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DDX15 Double Nickase Plasmid (h) - sc-403959-NIC from Santa Cruz Biotechnology
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DDX15 Double Nickase Plasmid (h2) - sc-403959-NIC-2 from Santa Cruz Biotechnology
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DDX15 CRISPR Activation Plasmid (h) - sc-403959-ACT from Santa Cruz Biotechnology
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DDX15 CRISPR Activation Plasmid (h2) - sc-403959-ACT-2 from Santa Cruz Biotechnology
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DDX15 Lentiviral Activation Particles (h) - sc-403959-LAC from Santa Cruz Biotechnology
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DDX15 Lentiviral Activation Particles (h2) - sc-403959-LAC-2 from Santa Cruz Biotechnology
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DDX15 siRNA (h) - sc-62198 from Santa Cruz Biotechnology
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DDX15 shRNA Plasmid (h) - sc-62198-SH from Santa Cruz Biotechnology
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DDX15 shRNA (h) Lentiviral Particles - sc-62198-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU067811 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7212 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7212 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04704 from Sigma-Aldrich
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DHX15 siRNA (Human) - CRH1174 from Cohesion Biosciences
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DHX15 RNAi - H00001665-R02 from Novus Biologicals
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DHX15 - MBS8211461 from MyBioSource
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shRNA set against Human DHX15 (NM_001358.2) - SHH277817 from Creative biogene
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shRNA set against Human DHX15(NM_001358.2) - SHH004403 from Creative biogene
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Human DHX15 siRNA - orb261676 from Biorbyt
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DHX15 shRNA Plasmid (Human) - CHH1174 from Cohesion Biosciences
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DHX15 miRNA 3'UTR clone - MiUTR1H-02815 from Creative biogene
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