| Gene Symbol |
MGST2
|
| Entrez Gene |
4258
|
| Alt Symbol |
GST2, MGST-II
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
microsomal glutathione S-transferase 2
|
| Other Description |
microsomal GST-2|microsomal GST-II
|
| Swissprots |
D6RBB5 Q99735 Q7Z5B8
|
| Accessions |
AAP88934 CAY55978 EAX05111 EAX05112 EAX05113 Q99735 AA122237 AK130948 AK307231 BC025416 AAH25416 BE312976 CR407640 CAG28568 DB257575 DQ893384 ABM84310 DQ896704 ABM87703 U77604 AAC51768 XM_006714221 XP_006714284 XM_011531972 XP_011530274 NM_001204366 NP_001191295 NM_001204367 NP_001191296 NM_001204368 NP_001191297 NM_002413 NP_002404
|
| Function |
Can catalyze the production of LTC4 from LTA4 and reduced glutathione. Can catalyze the conjugation of 1-chloro-2,4- dinitrobenzene with reduced glutathione.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Microsome membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Liver, spleen, skeletal muscle, heart, adrenals, pancreas, prostate, testis, fetal liver, and fetal spleen. Very low expression in lung, brain, placenta and bone marrow.
|
| Top Pathways |
Chemical carcinogenesis, Glutathione metabolism, Metabolism of xenobiotics by cytochrome P450, Drug metabolism - cytochrome P450
|