Gene Symbol | MGST2 |
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Entrez Gene | 4258 |
Alt Symbol | GST2, MGST-II |
Species | Human |
Gene Type | protein-coding |
Description | microsomal glutathione S-transferase 2 |
Other Description | microsomal GST-2|microsomal GST-II |
Swissprots | D6RBB5 Q99735 Q7Z5B8 |
Accessions | AAP88934 CAY55978 EAX05111 EAX05112 EAX05113 Q99735 AA122237 AK130948 AK307231 BC025416 AAH25416 BE312976 CR407640 CAG28568 DB257575 DQ893384 ABM84310 DQ896704 ABM87703 U77604 AAC51768 XM_006714221 XP_006714284 XM_011531972 XP_011530274 NM_001204366 NP_001191295 NM_001204367 NP_001191296 NM_001204368 NP_001191297 NM_002413 NP_002404 |
Function | Can catalyze the production of LTC4 from LTA4 and reduced glutathione. Can catalyze the conjugation of 1-chloro-2,4- dinitrobenzene with reduced glutathione. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Microsome membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
Tissue Specificity | Liver, spleen, skeletal muscle, heart, adrenals, pancreas, prostate, testis, fetal liver, and fetal spleen. Very low expression in lung, brain, placenta and bone marrow. |
Top Pathways | Chemical carcinogenesis, Glutathione metabolism, Metabolism of xenobiotics by cytochrome P450, Drug metabolism - cytochrome P450 |
MGST2 CRISPR/Cas9 KO Plasmid (h) - sc-417742 from Santa Cruz Biotechnology
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MGST2 HDR Plasmid (h) - sc-417742-HDR from Santa Cruz Biotechnology
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MGST2 Double Nickase Plasmid (h) - sc-417742-NIC from Santa Cruz Biotechnology
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MGST2 Double Nickase Plasmid (h2) - sc-417742-NIC-2 from Santa Cruz Biotechnology
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MGST2 CRISPR Activation Plasmid (h) - sc-417742-ACT from Santa Cruz Biotechnology
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MGST2 CRISPR Activation Plasmid (h2) - sc-417742-ACT-2 from Santa Cruz Biotechnology
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MGST2 Lentiviral Activation Particles (h) - sc-417742-LAC from Santa Cruz Biotechnology
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MGST2 Lentiviral Activation Particles (h2) - sc-417742-LAC-2 from Santa Cruz Biotechnology
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MGST2 siRNA (h) - sc-62610 from Santa Cruz Biotechnology
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MGST2 shRNA Plasmid (h) - sc-62610-SH from Santa Cruz Biotechnology
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MGST2 shRNA (h) Lentiviral Particles - sc-62610-V from Santa Cruz Biotechnology
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MGST2 RNAi - H00004258-R01 from Novus Biologicals
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MISSION® esiRNA - EHU076501 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN13307 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13307 from Sigma-Aldrich
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MGST2 siRNA (Human) - CRH2896 from Cohesion Biosciences
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shRNA set against Human MGST2 (NM_002413.4) - SHH341731 from Creative biogene
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MGST2 shRNA Plasmid (Human) - CHH2896 from Cohesion Biosciences
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MGST2 miRNA 3'UTR clone - MiUTR3H-04356 from Creative biogene
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