| Gene Symbol |
NCAPH
|
| Entrez Gene |
23397
|
| Alt Symbol |
BRRN1, CAP-H
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
non-SMC condensin I complex, subunit H
|
| Other Description |
barren homolog 1|chromosome-associated protein H|condensin complex subunit 2
|
| Swissprots |
B4E189 Q15003 Q8TB87
|
| Accessions |
CCQ43504 EAW71370 Q15003 AK291053 BAF83742 AK299248 BAG61279 AK303725 BAG64701 AK308050 AK310649 BC024211 AAH24211 BI559873 BI560881 D38553 BAA07556 DQ893432 ABM84358 EU176758 ABW03559 XM_005263908 XP_005263965 XM_006712388 XP_006712451 NM_001281710 NP_001268639 NM_001281711 NP_001268640 NM_001281712 NP_001268641 NM_015341 NP_056156
|
| Function |
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. {ECO:0000269|PubMed:11136719}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:11694586}. Cytoplasm {ECO:0000269|PubMed:11694586}. Chromosome {ECO:0000269|PubMed:11694586}. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.
|
| Tissue Specificity |
Widely expressed at low level. Expressed in proliferating cells. {ECO:0000269|PubMed:11694586}.
|
![Western Blot: NCAPH Overexpression Lysate (Adult Normal) [NBL1-13505] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for NCAPH.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8185_NCAPH%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-13505-img0002.jpg)