Gene Symbol | PARD6G |
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Entrez Gene | 84552 |
Alt Symbol | PAR-6G, PAR6gamma |
Species | Human |
Gene Type | protein-coding |
Description | par-6 family cell polarity regulator gamma |
Other Description | PAR-6 gamma protein|PAR6D|par-6 partitioning defective 6 homolog gamma|partitioning defective 6 homolog gamma |
Swissprots | Q9BYG4 A8QM57 |
Accessions | CCQ43766 EAW66649 Q9BYG4 AA502508 AB043635 BAA96236 AB044556 BAB40757 AB178535 BAF92014 AB178536 BAF92015 AK128802 BC060797 AAH60797 NM_032510 NP_115899 |
Function | Adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. The PARD6-PARD3 complex links GTP- bound Rho small GTPases to atypical protein kinase C proteins (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm. Cell membrane {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. |
Tissue Specificity | Widely expressed, with a higher expression in fetal and adult kidney. |
Top Pathways | Tight junction, Endocytosis, Hippo signaling pathway, Rap1 signaling pathway |
PARD6G CRISPR/Cas9 KO Plasmid (h) - sc-403179 from Santa Cruz Biotechnology
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PARD6G HDR Plasmid (h) - sc-403179-HDR from Santa Cruz Biotechnology
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PARD6G Double Nickase Plasmid (h) - sc-403179-NIC from Santa Cruz Biotechnology
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PARD6G Double Nickase Plasmid (h2) - sc-403179-NIC-2 from Santa Cruz Biotechnology
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PARD6G CRISPR Activation Plasmid (h) - sc-403179-ACT from Santa Cruz Biotechnology
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PARD6G CRISPR Activation Plasmid (h2) - sc-403179-ACT-2 from Santa Cruz Biotechnology
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PARD6G Lentiviral Activation Particles (h) - sc-403179-LAC from Santa Cruz Biotechnology
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PARD6G Lentiviral Activation Particles (h2) - sc-403179-LAC-2 from Santa Cruz Biotechnology
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PARD6G siRNA (h) - sc-76050 from Santa Cruz Biotechnology
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PARD6G shRNA Plasmid (h) - sc-76050-SH from Santa Cruz Biotechnology
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PARD6G shRNA (h) Lentiviral Particles - sc-76050-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN16336 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16336 from Sigma-Aldrich
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PARD6G siRNA (Human) - CRJ3522 from Cohesion Biosciences
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PARD6G HDR Plasmid (h2) - sc-403179-HDR-2 from Santa Cruz Biotechnology
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PARD6G CRISPR/Cas9 KO Plasmid (h2) - sc-403179-KO-2 from Santa Cruz Biotechnology
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shRNA set against Human PARD6G (NM_032510.3) - SHH370704 from Creative biogene
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PARD6G shRNA Plasmid (Human) - CHJ3522 from Cohesion Biosciences
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PARD6G miRNA 3'UTR clone - MiUTR1H-07514 from Creative biogene
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