Gene Symbol | CELE_F58A4.3 |
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Entrez Gene | 176359 |
Alt Symbol | - |
Species | C. elegans |
Gene Type | protein-coding |
Description | HCP-3 |
Other Description | - |
Swissprots | P34470 |
Accessions | CAA80160 P34470 NM_066727 NP_499128 |
Function | Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. Not required for chromosome segregation during meiosis. {ECO:0000269|PubMed:10524621, ECO:0000269|PubMed:11402065, ECO:0000269|PubMed:14522947, ECO:0000269|PubMed:16273096}. |
Subcellular Location | Nucleus. Chromosome, centromere, kinetochore. Note=Localizes exclusively in the kinetochore domain of centromeres. |
Recombinant Histone H3-like centromeric protein hcp-3(hcp-3) - CSB-YP335943CXY CSB-EP335943CXY CSB-BP335943CXY CSB-MP335943CXY from Cusabio
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Histone H3-like centromeric protein hcp-3 (hcp-3), Recombinant Protein - MBS1237229 from MyBioSource
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