MC4R

Gene Symbol MC4R
Entrez Gene 4160
Alt Symbol -
Species Human
Gene Type protein-coding
Description melanocortin 4 receptor
Other Description MC4-R|melanocortin receptor 4
Swissprots Q16317 B2RAC3 P32245 Q3MIJ6
Accessions AAA35791 AAB33341 AAO92061 ABK35297 ABK35298 ABK35299 ABK35300 AFV34058 AFV34059 AFV34060 AFV34061 AFV34062 EAW63105 P32245 AK314130 BAG36820 BC069172 AAH69172 BC101802 AAI01803 BC111992 AAI11993 DA362673 NM_005912 NP_005903
Function Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP). {ECO:0000269|PubMed:12646665}.
Subcellular Location Cell membrane; Multi-pass membrane protein.
Tissue Specificity Brain, placental, and gut tissues.
Top Pathways Neuroactive ligand-receptor interaction

MC4-R (C-19) - sc-6879 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MC4-R (C-19): sc-6879. Western blot analysis of MC4-R expression in mouse cerebellum (A), rat cerebellum (B) and mouse brain (C) extracts.

MC4-R (H-60) - sc-28992 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
MC4-R (H-60): sc-28992. Western blot analysis of MC4-R expression in MCF7 whole cell lysate (A) and rat brain (B), human hippocampus (C) and rat cerebellum (D) tissue extracts.

MC4-R (C-10) - sc-55567 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MC4-R (C-10): sc-55567. Western blot analysis of MC4-R expression in EOC 20 whole cell lysate.

MC4-R (S-18) - sc-6881 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MC4-R (S-18): sc-6881. Western blot analysis of MC4-R expression in EOC 20 whole cell lysate (A) and human hippocampus (B) and rat cerebellum (C) tissue extracts.

Anti-MC4 Receptor antibody - ab106596 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-MC4 Receptor antibody (ab106596) at 1 µg/mlLane 1 : Rat brain tissue lysate Lane 2 : Rat brain tissue lysate with blocking peptideLysates/proteins at 15 µg per lane.

Anti-MC4 Receptor antibody - ab75506 from Abcam

Prices $392.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab75506 stained U-87 MG cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab75506 at 5µg/ml overnight at +4°C. The secondary antibody (green) was DyLight® 488 goat anti- rabbit (ab96899) IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-MC4 Receptor antibody - ab97432 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-MC4 Receptor antibody (ab97432) at 1 µg/mlLane 1 : Brain (Human) Tissue Lysate - adult normal tissue (ab29466)Lane 2 : Spinal Cord (Human) Tissue Lysate - adult normal tissue (ab29188)Lane 3 : Placenta (Human) Tissue Lysate - adult normal tissue (ab29745)Lane 4 : Small Intestine (Human) Tissue Lysate - adult normal tissue (ab29276)Lane 5 : Caco 2 (Human colonic carcinoma cell line) Whole Cell LysateLane 6 : JEG-3 (Human placental choriocarcinoma cell line) Whole Cell LysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-MC4 Receptor antibody - ab24233 from Abcam

Prices $398.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab24233 staining MC4 Receptor in Rat brain tissue sections by Immunohistochemistry (IHC-Fr - frozen sections). Tissue was fixed with paraformaldehyde and blocked with 5% serum for 1 hour at 21°C. Samples were incubated with primary antibody (1/1000 in TPBS + normal goat serum) for 19 hours at 4°C. A biotin-conjugated Goat anti-rabbit IgG polyclonal (1/200) was used as the secondary antibody.See Abreview

Anti-MC4 Receptor antibody [EPR6534(2)(ABC)] - ab150419 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6534(2)(ABC)
All lanes : Anti-MC4 Receptor antibody [EPR6534(2)(ABC)] (ab150419) at 1/1000 dilutionLane 1 : 293T cell lysateLane 2 : MCF7 cell lysateLane 3 : JAR cell lysateLane 4 : SH-SY5Y cell lysateLane 5 : C6 cell lysateLane 6 : RAW 264.7 cell lysateLane 7 : PC12 cell lysateLane 8 : NIH 3T3 cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP at 1/2000 dilution

Anti-MC4R / Melanocortin 4 Receptor Antibody (C-Terminus) - LS-C8980 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-MC4R / Melanocortin 4 Receptor Antibody - LS-C147048 from LifeSpan Bioscience

Prices $410.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MC4R / Melanocortin 4 Receptor Antibody (aa306-332, Biotin) - LS-C183963 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MC4R / Melanocortin 4 Receptor Antibody (aa306-332, CF) - LS-C183964 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MC4R / Melanocortin 4 Receptor Antibody (aa306-332, FITC) - LS-C183965 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MC4R / Melanocortin 4 Receptor Antibody (aa306-332, Biotin) - LS-C183966 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MC4R / Melanocortin 4 Receptor Antibody (aa306-332, CF) - LS-C183967 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MC4R / Melanocortin 4 Receptor Antibody (aa306-332, FITC) - LS-C183968 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MC4R / Melanocortin 4 Receptor Antibody (N-Terminus) - LS-C146468 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
MC4R antibody LS-C146468 Western blot of ACHN Cell lysate. Antibody concentration 1 ug/ml.

Anti-MC4R / Melanocortin 4 Receptor Antibody (aa306-332) - LS-C191030 from LifeSpan Bioscience

Prices $530.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MC4R / Melanocortin 4 Receptor Antibody (aa306-332) - LS-C191029 from LifeSpan Bioscience

Prices $530.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MC4R / Melanocortin 4 Receptor Antibody (Glu315) - LS-C177203 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of MC4-R (E315) pAb in extracts from MCF-7 cells.

Anti-MC4R / Melanocortin 4 Receptor Antibody (aa281-330) - LS-C120738 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from MCF-7 cells, using MC4R Antibody. The lane on the right is treated with the synthesized peptide.

Anti-MC4R / Melanocortin 4 Receptor Antibody (aa306-332) - LS-C191031 from LifeSpan Bioscience

Prices $530.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MC4R / Melanocortin 4 Receptor Antibody (aa306-332) - LS-C191032 from LifeSpan Bioscience

Prices $530.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MC4R / Melanocortin 4 Receptor Antibody - LS-C195931 from LifeSpan Bioscience

Prices $710.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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