PAF1

Gene Symbol PAF1
Entrez Gene 54623
Alt Symbol F23149_1, PD2
Species Human
Gene Type protein-coding
Description Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)
Other Description RNA polymerase II-associated factor 1 homolog|pancreatic differentiation protein 2
Swissprots M0QX35 Q9NUU9 O75239 Q8N7H5 Q9H166
Accessions AAC25503 EAW56880 EAW56881 EAW56882 EAW56883 Q8N7H5 AF086555 AJ401156 CAC20564 AK001985 BAA92020 AK098423 BAC05305 AK294625 BAG57806 BC000017 AAH00017 BC013402 AAH13402 DA821359 DQ891839 ABM82765 DQ895026 ABM85952 NM_001256826 NP_001243755 NM_019088 NP_061961 NR_046384
Function Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non- phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex
Subcellular Location Nucleus {ECO:0000269|PubMed:16491129}. Note=Punctuate distribution throughout the nucleus except in nucleoli and the perinuclear chromatin.

Paf1 CRISPR/Cas9 KO Plasmid (h) - sc-417797 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Paf1 HDR Plasmid (h) - sc-417797-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Paf1 Double Nickase Plasmid (h) - sc-417797-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Paf1 Double Nickase Plasmid (h2) - sc-417797-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Paf1 CRISPR Activation Plasmid (h) - sc-417797-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Paf1 CRISPR Activation Plasmid (h2) - sc-417797-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Paf1 Lentiviral Activation Particles (h) - sc-417797-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Paf1 Lentiviral Activation Particles (h2) - sc-417797-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Paf1 siRNA (h) - sc-76034 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Paf1 shRNA Plasmid (h) - sc-76034-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Paf1 shRNA (h) Lentiviral Particles - sc-76034-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU080281 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN16270 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16270 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR02868 from Sigma-Aldrich

Category miRNA

PAF1 siRNA (Human) - CRJ0159 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human PAF1 (NM_019088.3) - SHH369988 from Creative biogene

Category siRNA
Species Reactivities Human

Human PAF1 siRNA - orb270660 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PAF1 shRNA Plasmid (Human) - CHJ0159 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PAF1 miRNA 3'UTR clone - MiUTR3H-11275 from Creative biogene

Species Reactivities Human
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