PAF1

Gene Symbol PAF1
Entrez Gene 54623
Alt Symbol F23149_1, PD2
Species Human
Gene Type protein-coding
Description Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)
Other Description RNA polymerase II-associated factor 1 homolog|pancreatic differentiation protein 2
Swissprots M0QX35 Q9NUU9 O75239 Q8N7H5 Q9H166
Accessions AAC25503 EAW56880 EAW56881 EAW56882 EAW56883 Q8N7H5 AF086555 AJ401156 CAC20564 AK001985 BAA92020 AK098423 BAC05305 AK294625 BAG57806 BC000017 AAH00017 BC013402 AAH13402 DA821359 DQ891839 ABM82765 DQ895026 ABM85952 NM_001256826 NP_001243755 NM_019088 NP_061961 NR_046384
Function Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non- phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex
Subcellular Location Nucleus {ECO:0000269|PubMed:16491129}. Note=Punctuate distribution throughout the nucleus except in nucleoli and the perinuclear chromatin.

PAF1 (D9G9X) Rabbit mAb - 12883 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D9G9X
Western blot analysis of extracts from various cell lines using PAF1 (D9G9X) Rabbit mAb.

Paf1 (H-191) - sc-367667 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Paf1 (H-191): sc-367667. Western blot analysis of Paf1 expression in non-transfected 293T: sc-117752 (A), mouse Paf1 transfected 293T: sc-110302 (B), HeLa (C), A-431 (D) and NCI-H1299 (E) whole cell lysates.

Paf1 (N-14) - sc-74795 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Paf1 (N-14): sc-74795. Western blot analysis of Paf1 expression in non-transfected: sc-117752 (A) and mouse Paf1 transfected: sc-110302 (B) 293T whole cell lysates.

Paf1 (P-18) - sc-74796 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Paf1 (P-18): sc-74796. Western blot analysis of Paf1 expression in non-transfected: sc-117752 (A) and mouse Paf1 transfected: sc-110302 (B) 293T whole cell lysates.

Paf1 (S-20) - sc-74797 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Paf1 (S-20): sc-74797. Western blot analysis of Paf1 expression in non-transfected: sc-117752 (A) and mouse Paf1 transfected: sc-110302 (B) 293T whole cell lysates.

Anti-PAF1 antibody - ab70638 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human lung carcinoma (left) and mouse renal cell carcinoma (right) tissues labelling PAF1 with ab70638 at 1/1000 (1µg/ml). Detection: DAB.

Anti-PAF1 antibody - ab84914 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab84914, at a 1/250 dilution, staining PAF1 in formalin fixed, paraffin embedded human small cell lung cancer by Immunohistochemistry using DAB staining.

Anti-PAF1 antibody - ab129786 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-PAF1 antibody (ab129786) at 1/100 dilution + HeLa cell lysate at 35 µg

Anti-PAF1 antibody [EPR5311(2)] - ab181120 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5311(2)
Anti-PAF1 antibody [EPR5311(2)] (ab181120) at 1/10000 dilution + K562 cell lysate at 20 µgSecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-PAF1 antibody - ChIP Grade - ab20662 from Abcam

Prices $382.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PAF1 antibody - ChIP Grade (ab20662) at 1 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate Lane 2 : HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate with Human PAF1 peptide (ab23389) at 1 µg/mlLysates/proteins at 20 µg per lane.SecondaryGoat polyclonal to Rabbit IgG (Alexa Fluor® 680) (ab28446) at 1/10000 dilution

Anti-PD2 / PAF1 Antibody (aa75-125) - LS-C92974 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PD2 / PAF1 Antibody (aa475-525) - LS-C92975 from LifeSpan Bioscience

Prices $575.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PD2 / PAF1 Antibody (aa439-467, APC) - LS-C265465 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PD2 / PAF1 Antibody (aa439-467, AP) - LS-C265464 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PD2 / PAF1 Antibody (aa439-467, Biotin) - LS-C265467 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PD2 / PAF1 Antibody (aa439-467, Azide-free, HRP) - LS-C265468 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PD2 / PAF1 Antibody (aa439-467, PE) - LS-C265469 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PD2 / PAF1 Antibody (aa439-467, FITC) - LS-C265470 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PD2 / PAF1 Antibody (aa438-467) - LS-C323755 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PD2 / PAF1 Antibody - LS-C347707 from LifeSpan Bioscience

Prices $405.00
Sizes 25 µg
Host Rabbit
Clonality Polyclonal

Anti-PD2 / PAF1 Antibody (aa394-443) - LS-C145310 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PAF1 antibody LS-C145310 Western blot of Jurkat Cell lysate. Antibody concentration 1 ug/ml.

Anti-PD2 / PAF1 Antibody (aa112-161) - LS-C145311 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PAF1 antibody LS-C145311 Western blot of HepG2 Cell lysate. Antibody concentration 1 ug/ml.

Anti-PD2 / PAF1 Antibody (aa475-525) - LS-C287097 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human and Mouse Paf1 by Immunohistochemistry. Sample: FFPE sections of human lung carcinoma (left) and mouse renal cell carcinoma (right). Antibody: Affinity purified rabbit anti-Paf1 used at a dilution of 1:1000 (1 ug/ml). Detection: DAB.

Anti-PD2 / PAF1 Antibody (aa475-525) - LS-C286611 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human Paf1 by Immunohistochemistry. Sample: FFPE section of human pancreatic islet cell tumor. Antibody: Affinity purified rabbit anti-Paf1 used at a dilution of 1:250.

Anti-PD2 / PAF1 Antibody (aa75-125) - LS-C287098 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Mouse and Rat Paf1 by Western Blot. Samples: Whole cell lysate (50 ug) from NIH3T3, TCMK-1, 4T1, CT26.WT, and rat C6 cells. Antibodies: Affinity purified rabbit anti-Paf1 antibody used for WB at 0.2 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.
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