Gene Symbol | TIMP3 |
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Entrez Gene | 7078 |
Alt Symbol | HSMRK222, K222, K222TA2, SFD |
Species | Human |
Gene Type | protein-coding |
Description | TIMP metallopeptidase inhibitor 3 |
Other Description | MIG-5 protein|TIMP-3|metalloproteinase inhibitor 3|protein MIG-5|tissue inhibitor of metalloproteinases 3 |
Swissprots | Q5THV4 P35625 Q9UGS2 Q9UC74 B2RBY9 |
Accessions | AAB17602 AAB68799 AAC50393 CAA82918 EAW60038 P35625 AF035289 AK098517 AK298126 BAG60406 AK314871 BAG37386 BC013086 BC014277 AAH14277 BT006848 AAP35494 CR456593 CAG30479 CU013193 CAK54624 CU013481 CAK54923 D45917 BAA08348 DQ892581 ABM83507 DQ895798 ABM86724 L15078 AAA21815 S78453 AAB34532 U02571 AAA17672 U14394 AAB60373 U67195 AAB07547 X76227 CAA53813 X80791 NM_000362 NP_000353 |
Function | Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15. |
Subcellular Location | Secreted, extracellular space, extracellular matrix. |
Top Pathways | MicroRNAs in cancer, Proteoglycans in cancer |
TIMP-3 CRISPR/Cas9 KO Plasmid (h) - sc-401255 from Santa Cruz Biotechnology
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TIMP-3 HDR Plasmid (h) - sc-401255-HDR from Santa Cruz Biotechnology
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TIMP-3 Double Nickase Plasmid (h) - sc-401255-NIC from Santa Cruz Biotechnology
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TIMP-3 Double Nickase Plasmid (h2) - sc-401255-NIC-2 from Santa Cruz Biotechnology
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TIMP-3 CRISPR Activation Plasmid (h) - sc-401255-ACT from Santa Cruz Biotechnology
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TIMP-3 CRISPR Activation Plasmid (h2) - sc-401255-ACT-2 from Santa Cruz Biotechnology
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TIMP-3 Lentiviral Activation Particles (h) - sc-401255-LAC from Santa Cruz Biotechnology
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TIMP-3 Lentiviral Activation Particles (h2) - sc-401255-LAC-2 from Santa Cruz Biotechnology
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TIMP-3 siRNA (h) - sc-37022 from Santa Cruz Biotechnology
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TIMP-3 shRNA Plasmid (h) - sc-37022-SH from Santa Cruz Biotechnology
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TIMP-3 shRNA (h) Lentiviral Particles - sc-37022-V from Santa Cruz Biotechnology
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TIMP-3 siRNA (h2) - sc-44331 from Santa Cruz Biotechnology
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TIMP-3 shRNA Plasmid (h2) - sc-44331-SH from Santa Cruz Biotechnology
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TIMP-3 shRNA (h2) Lentiviral Particles - sc-44331-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN21369 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21369 from Sigma-Aldrich
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TIMP3 siRNA (Human) - CRH4847 from Cohesion Biosciences
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TIMP3 - MBS8232030 from MyBioSource
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shRNA set against Human TIMP3 (NM_000362.4) - SHH427544 from Creative biogene
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shRNA set against Human TIMP3(NM_000362.4) - SHL071702 from Creative biogene
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TIMP3 shRNA Plasmid (Human) - CHH4847 from Cohesion Biosciences
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TIMP3 miRNA 3'UTR clone - MiUTR1H-10418 from Creative biogene
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