TIMP3

Gene Symbol TIMP3
Entrez Gene 7078
Alt Symbol HSMRK222, K222, K222TA2, SFD
Species Human
Gene Type protein-coding
Description TIMP metallopeptidase inhibitor 3
Other Description MIG-5 protein|TIMP-3|metalloproteinase inhibitor 3|protein MIG-5|tissue inhibitor of metalloproteinases 3
Swissprots Q5THV4 P35625 Q9UGS2 Q9UC74 B2RBY9
Accessions AAB17602 AAB68799 AAC50393 CAA82918 EAW60038 P35625 AF035289 AK098517 AK298126 BAG60406 AK314871 BAG37386 BC013086 BC014277 AAH14277 BT006848 AAP35494 CR456593 CAG30479 CU013193 CAK54624 CU013481 CAK54923 D45917 BAA08348 DQ892581 ABM83507 DQ895798 ABM86724 L15078 AAA21815 S78453 AAB34532 U02571 AAA17672 U14394 AAB60373 U67195 AAB07547 X76227 CAA53813 X80791 NM_000362 NP_000353
Function Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15.
Subcellular Location Secreted, extracellular space, extracellular matrix.
Top Pathways MicroRNAs in cancer, Proteoglycans in cancer

TIMP3 (D74B10) Rabbit mAb - 5673 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D74B10
Western blot analysis of extracts from A-431, NIH/3T3 and COS-7 cells, using TIMP3 (D74B10) Rabbit mAb.

TIMP-3 (B-2) - sc-373839 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TIMP-3 (B-2): sc-373839. Western blot analysis of human recombinant TIMP-3.

TIMP-3 (C-20) - sc-6836 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TIMP-3 (C-20): sc-6836. Western blot analysis of human recombinant TIMP-3.

TIMP-3 (E-2) - sc-373842 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TIMP-3 (E-2): sc-373842. Western blot analysis of human recombinant TIMP-3.

TIMP-3 (G-16) - sc-27286 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TIMP-3 (G-16): sc-27286. Immunoperoxidase staining of formalin fixed, paraffin-embedded human pancreas tissue showing cytoplasmic staining of exocrine glandular cells.

TIMP-3 (W-18) - sc-9906 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TIMP-3 (W-18): sc-9906. Western blot analysis of human recombinant TIMP-3.

TIMP-3 (H-55) - sc-30075 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TIMP-3 (H-55): sc-30075. Western blot analysis of TIMP-3 expression in HeLa (A) and NIH/3T3 (B) whole cell lysates and rat brain (C) and rat placenta (D) tissue extracts.

Anti-TIMP3 antibody - ab2169 from Abcam

Prices $372.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal

Anti-TIMP3 antibody - ab93637 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab93637, at 1/100 dilution, staining TIMP3 in formalin-fixed, paraffin-embedded Human kidney tissue by Immunohistochemistry.

Anti-TIMP3 antibody [MM0036-7D3] - ab61316 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MM0036-7D3
ab61316 at 1/200 dilution, staining TIMP3 in human placenta tissue section by Immunohistochemistry (Formalin/ PFA fixed paraffin-embedded sections).

Anti-TIMP3 antibody - Aminoterminal end - ab56194 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TIMP3 antibody - Carboxyterminal end - ab39185 from Abcam

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab39185 stained HeLa cells. The cells were 100% methanol fixed (5 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab39185, 1µg/ml) overnight at +4°C. The secondary antibody (green) was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-TIMP3 antibody - Loop 1 - ab39184 from Abcam

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-TIMP3 antibody - Loop 1 (ab39184)Lane 1 : Human TIMP3Lane 2 : Mouse TIMP3Lane 3 : crude control (preparation of extracellular matrix from BHK cells producing recombinant human TIMP-3)

Anti-TIMP3 antibody - Loop 2 - ab39206 from Abcam

Prices $379.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab39206 (4µg/ml) staining TIMP3 in human placenta.Sections were stained using an automated system (DAKO Autostainer Plus ), at room temperature: sections were rehydrated and antigen retrieved with the Dako 3 in 1 AR buffers EDTA pH 9.0 . Slides were peroxidase blocked in 3% H2O2 in methanol for 10 mins. They were then blocked with Dako Protein block for 10 minutes (containing casein 0.25% in PBS) then incubated with primary antibody for 20 min and detected with Dako envision flex amplification kit for 30 minutes. Colorimetric detection was completed with Diaminobenzidine for 5 minutes. Slides were counterstained with Haematoxylin and coverslipped under DePeX. Please note that for manual staining we recommend to optimize the primary antibody concentration and incubation time (overnight incubation), and amplification may be required.

Anti-TIMP3 antibody - Loop 3 - ab39205 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TIMP3 Antibody (aa113-139) - LS-C161892 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human breast carcinoma reacted with TIMP3 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-TIMP3 Antibody (aa1-211) IHC-plus™ - LS-B11703 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Human Colon, Myenteric Plexus: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-TIMP3 Antibody (N-Terminus) - LS-C47071 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TIMP3 Antibody (aa170-188, clone 136-13H4) - LS-C85461 from LifeSpan Bioscience

Prices $650.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 136-13H4

Anti-TIMP3 Antibody (aa198-211) - LS-C132519 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TIMP3 Antibody (C-Terminus) - LS-C132520 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TIMP3 Antibody (C-Terminus) - LS-C95907 from LifeSpan Bioscience

Prices $415.00, $690.00
Sizes 500 µl, 1 ml
Host Rabbit
Clonality Polyclonal
Formalin-fixed, paraffin-embedded human testis stained with TIMP-3 antibody LS-C95907.

Anti-TIMP3 Antibody - LS-C149149 from LifeSpan Bioscience

Prices $265.00
Sizes 100 µg
Host Chicken
Clonality Polyclonal

Anti-TIMP3 Antibody (C-Terminus, Magnetic beads) - LS-C171707 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TIMP3 Antibody (C-Terminus, Sepharose) - LS-C171708 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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