| Gene Symbol |
GIMAP5
|
| Entrez Gene |
55340
|
| Alt Symbol |
HIMAP3, IAN-5, IAN4, IAN4L1, IAN5, IMAP3, IROD
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
GTPase, IMAP family member 5
|
| Other Description |
GTPase IMAP family member 5|immune associated nucleotide 4 like 1|immune-associated nucleotide-binding protein 5|immunity associated protein 3|immunity-associated nucleotide 5 protein|inhibitor of radiation- and OA-induced apoptosis, Irod/Ian5
|
| Swissprots |
Q9NUK9 Q96F15 Q96NE4 D3DWZ5 Q6IA75
|
| Accessions |
EAL24486 EAW54092 EAW54093 EAW54094 Q96F15 AK002158 BAA92115 AK055568 BAB70958 AK297881 BAG60204 AL557446 AV762634 BC011732 AAH11732 BC033688 CA431916 CR457280 CAG33561 JF432844 ADZ16061 NM_018384 NP_060854
|
| Function |
Required for mitochondrial integrity and T-cell survival. May contribute to T-cell quiescence (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Mitochondrion outer membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Lysosome {ECO:0000269|PubMed:14724691, ECO:0000269|PubMed:21487483}.
|
| Tissue Specificity |
Widely expressed with high levels in lymph node and spleen. High expression found in CD4 and CD8-positive T- cells and monocytes with very low levels in B-lymphocytes. Highly expressed in B-lymphocyte-derived neoplasms. {ECO:0000269|PubMed:14724691}.
|