| Gene Symbol |
APOBEC1
|
| Entrez Gene |
339
|
| Alt Symbol |
APOBEC-1, BEDP, CDAR1, HEPR
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
|
| Other Description |
C->U-editing enzyme APOBEC-1|apolipoprotein B mRNA editing enzyme complex-1|apolipoprotein B mRNA-editing enzyme 1
|
| Swissprots |
Q9UE64 Q9UM71 P41238
|
| Accessions |
AAD09566 BAA23882 EAW88660 EAW88661 P41238 AI380263 AI862416 BC096158 AAH96158 BC096159 BC096160 BC096161 BC101404 BC101405 BC101972 AAI01973 BC101973 AAI01974 BC144708 BC172305 AAI72305 L25877 AAA86766 L26234 AAA64230 U72890 AAD09567 U72891 AAD00185 U78720 AAD10701 NM_001304566 NP_001291495 NM_001644 NP_001635 NM_005889 NP_005880
|
| Function |
Catalytic component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the APOB mRNA. Also involved in CGA (Arg) to UGA (Stop) editing in the NF1 mRNA. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. {ECO:0000269|PubMed:11727199}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:22580899}.
|
| Tissue Specificity |
Expressed exclusively in the small intestine.
|
![Western Blot: APOBEC1 Overexpression Lysate (Adult Normal) [NBL1-07612] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for APOBEC1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/13856_APOBEC1%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-07612-img0002.jpg)
![Western Blot: APOBEC1 Overexpression Lysate (Adult Normal) [NBP2-05621] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for APOBEC1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/10506_APOBEC1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-05621-img0001.jpg)