Gene Symbol | ITM2B |
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Entrez Gene | 9445 |
Alt Symbol | ABRI, BRI, BRI2, BRICD2B, E25B, E3-16, FBD, RDGCA, imBRI2 |
Species | Human |
Gene Type | protein-coding |
Description | integral membrane protein 2B |
Other Description | ABri/ADan amyloid peptide|BRICHOS domain containing 2B|immature BRI2|transmembrane protein BRI |
Swissprots | Q9NYH1 Q96B24 Q5W0A3 Q9Y287 |
Accessions | AAP88930 EAX08788 EAX08789 EAX08790 EAX08791 Q9Y287 AF086918 AAP97148 AF092128 AAD40370 AF136973 AAG49434 AF152462 AAD45280 AF246221 AAF66130 AK000503 BAA91210 AK027411 AK130048 BC000554 AAH00554 BC016148 AAH16148 BC018053 BT006863 AAP35509 DA087198 DQ890591 ABM92208 DQ893759 ABM84685 NM_021999 NP_068839 |
Function | Bri23 peptide prevents aggregation of APP beta-amyloid protein 42 peptide into toxic oligomers. |
Subcellular Location | Bri23 peptide: Secreted. Note=Detected in the cerebral spinal fluid (CSF). |
Tissue Specificity | Ubiquitous. Expressed in brain. |
ITM2B CRISPR/Cas9 KO Plasmid (h) - sc-403561 from Santa Cruz Biotechnology
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ITM2B HDR Plasmid (h) - sc-403561-HDR from Santa Cruz Biotechnology
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ITM2B Double Nickase Plasmid (h) - sc-403561-NIC from Santa Cruz Biotechnology
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ITM2B Double Nickase Plasmid (h2) - sc-403561-NIC-2 from Santa Cruz Biotechnology
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ITM2B CRISPR Activation Plasmid (h) - sc-403561-ACT from Santa Cruz Biotechnology
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ITM2B CRISPR Activation Plasmid (h2) - sc-403561-ACT-2 from Santa Cruz Biotechnology
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ITM2B Lentiviral Activation Particles (h) - sc-403561-LAC from Santa Cruz Biotechnology
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ITM2B Lentiviral Activation Particles (h2) - sc-403561-LAC-2 from Santa Cruz Biotechnology
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ITM2B siRNA (h) - sc-60869 from Santa Cruz Biotechnology
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ITM2B shRNA Plasmid (h) - sc-60869-SH from Santa Cruz Biotechnology
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ITM2B shRNA (h) Lentiviral Particles - sc-60869-V from Santa Cruz Biotechnology
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ITM2B RNAi - H00009445-R01 from Novus Biologicals
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MISSION® esiRNA - EHU001341 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10830 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10830 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07111 from Sigma-Aldrich
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ITM2B siRNA (Human) - CRH6264 from Cohesion Biosciences
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ITM2B, siRNA - MBS8228489 from MyBioSource
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shRNA set against Human ITM2B (NM_021999.4) - SHH321589 from Creative biogene
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Human ITM2B siRNA - orb266766 from Biorbyt
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ITM2B shRNA Plasmid (Human) - CHH6264 from Cohesion Biosciences
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ITM2B miRNA 3'UTR clone - MiUTR3H-06370 from Creative biogene
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