| Gene Symbol | POLR3A |
|---|---|
| Entrez Gene | 11128 |
| Alt Symbol | ADDH, HLD7, RPC1, RPC155, hRPC155 |
| Species | Human |
| Gene Type | protein-coding |
| Description | polymerase (RNA) III (DNA directed) polypeptide A, 155kDa |
| Other Description | DNA-directed RNA polymerase III largest subunit|DNA-directed RNA polymerase III subunit A|DNA-directed RNA polymerase III subunit RPC1|RNA polymerase III 155 kDa subunit|RNA polymerase III subunit C1|RNA polymerase III subunit C160|RNA polymerase III subunit RPC155-D |
| Swissprots | Q8TCW5 Q8IW34 O14802 |
| Accessions | EAW54617 O14802 AF021351 AAB86536 AK024744 AK026023 AK300329 BAH13260 AY091459 AAM12029 AY091460 AAM12030 AY091461 AAM12031 AY091462 AAM12032 BC014399 AAH14399 BC041089 AAH41089 CA449326 DA103416 DA353439 NM_007055 NP_008986 |
| Function | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity). Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsR |
| Subcellular Location | Nucleus. |
| Tissue Specificity | Expressed in the brain, in the cortex and the white matter (at protein level). {ECO:0000269|PubMed:21855841}. |
| Top Pathways | Cytosolic DNA-sensing pathway, Epstein-Barr virus infection, Purine metabolism, RNA polymerase, Pyrimidine metabolism |