POLR3A

Gene Symbol	POLR3A
Entrez Gene	11128
Alt Symbol	ADDH, HLD7, RPC1, RPC155, hRPC155
Species	Human
Gene Type	protein-coding
Description	polymerase (RNA) III (DNA directed) polypeptide A, 155kDa
Other Description	DNA-directed RNA polymerase III largest subunit|DNA-directed RNA polymerase III subunit A|DNA-directed RNA polymerase III subunit RPC1|RNA polymerase III 155 kDa subunit|RNA polymerase III subunit C1|RNA polymerase III subunit C160|RNA polymerase III subunit RPC155-D
Swissprots	Q8TCW5 Q8IW34 O14802
Accessions	EAW54617 O14802 AF021351 AAB86536 AK024744 AK026023 AK300329 BAH13260 AY091459 AAM12029 AY091460 AAM12030 AY091461 AAM12031 AY091462 AAM12032 BC014399 AAH14399 BC041089 AAH41089 CA449326 DA103416 DA353439 NM_007055 NP_008986
Function	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity). Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsR
Subcellular Location	Nucleus.
Tissue Specificity	Expressed in the brain, in the cortex and the white matter (at protein level). {ECO:0000269|PubMed:21855841}.
Top Pathways	Cytosolic DNA-sensing pathway, Epstein-Barr virus infection, Purine metabolism, RNA polymerase, Pyrimidine metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

Human POLR3A protein fragment - ab161308 from Abcam Category Protein Source Wheat germ Species Human

POLR3A Antibody Blocking Peptide - LS-E17617 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

POLR3A Partial Recombinant Protein - H00011128-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 2 µg Species Human

Human POLR3A protein - orb246411 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

POLR3A Blocking Peptide - 33R-1627 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

POLR3A - H00011128-Q01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

POLR3A - H00011128-Q01-10 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Source in vitro transl. Species Human

POLR3A - H00011128-Q01-25 from Acris Antibodies Category Protein Prices $520.00 Sizes 25 µg Source in vitro transl. Species Human

POLR3A fusion protein - ag11555 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

POLR3A fusion protein - ag11536 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

POLR3A (P68) Peptide - BS3292P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human DNA-directed RNA polymerase III subunit RPC1(POLR3A) ,partial - CSB-YP018343HU CSB-BP018343HU CSB-MP018343HU from Cusabio Category Protein Source Yeast or Baculovirus or Mammalian cell Species Human

Recombinant human DNA-directed RNA polymerase III subunit RPC1 - CSB-EP018343HU from Cusabio Category Protein Source E.coli Species Human

POLR3A protein - 80-1533 from Fitzgerald Category Protein Prices $495.00 Sizes 1 mg Source E.coli

POLR3A Recombinant Protein Antigen - NBP1-83204PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

POLR3A Protein - NBP2-32648PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

POLR3A Blocking Peptide - abx061292 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Chicken, Dog, Monkey, Pig, Rabbit, Zebrafish

POLR3A Peptide, Human - M34GP12104H from Creative Peptides Category Peptide Source Synthetic. Species Human

POLR3A Blocking Peptide - CBP5205 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Bovine, Chicken, Dog, Monkey, Pig, Rabbit, Zebrafish

POLR3A Recombinant Protein (OPCA01790) - OPCA01790 from Aviva Systems Biology Category Protein Prices $250.00 Sizes 50 µg Source Human

Recombinant human DNA-directed RNA polymerase III subunit RPC1 - AP70649 from Signalway Antibody Category Protein Prices $260.00, $735.00, $1,240.00, $1,975.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source E.coli Species Human

DNA-directed RNA polymerase III subunit RPC1, Recombinant Protein - MBS9420552 from MyBioSource Category Protein Prices $280.00, $665.00, $1,080.00, $1,690.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source E Coli Species Human

DNA-directed RNA polymerase III subunit RPC1 , Recombinant Protein - MBS1125598 from MyBioSource Category Protein Prices $190.00, $460.00, $750.00, $1,180.00 Sizes 50 µg (E-Coli), 200 µg (E-Coli), 500 µg (E-Coli), 1 mg (E-Coli) Source E Coli or Yeast or Baculovirus or Mammalian Cell

POLR3A, Recombinant Protein - MBS5308878 from MyBioSource Category Protein Prices $595.00 Sizes 1 mg Source E Coli

Recombinant Human POLR3A Protein (392-632 aa), His-SUMO-tagged - POLR3A-730H from Creative Biomart Category Protein Source E. coli Species Human

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