Gene Symbol | TMEM55B |
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Entrez Gene | 90809 |
Alt Symbol | C14orf9 |
Species | Human |
Gene Type | protein-coding |
Description | transmembrane protein 55B |
Other Description | ptdIns-4,5-P(2) 4-phosphatase type I|ptdIns-4,5-P2 4-Ptase I|type 1 PtdIns-4,5-P2 4-Ptase|type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase |
Swissprots | Q86U09 Q86T03 Q9BU67 Q8WUC0 Q9NSU8 B2RA35 |
Accessions | EAW66460 EAW66461 EAW66462 Q86T03 AK314021 BAG36732 AL137727 CAB70896 AM392745 CAL37623 BC002867 AAH02867 BC020947 AAH20947 BX161490 CAD61939 BX248025 CAD62347 CA430067 NM_001100814 NP_001094284 NM_144568 NP_653169 |
Function | Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate. Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4- bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3- monophosphate. {ECO:0000269|PubMed:16365287}. |
Subcellular Location | Late endosome membrane {ECO:0000269|PubMed:16365287}; Multi-pass membrane protein {ECO:0000269|PubMed:16365287}. Lysosome membrane {ECO:0000269|PubMed:16365287}; Multi-pass membrane protein {ECO:0000269|PubMed:16365287}. |
Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:16365287}. |
TMEM55B CRISPR/Cas9 KO Plasmid (h) - sc-410227 from Santa Cruz Biotechnology
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TMEM55B HDR Plasmid (h) - sc-410227-HDR from Santa Cruz Biotechnology
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TMEM55B Double Nickase Plasmid (h) - sc-410227-NIC from Santa Cruz Biotechnology
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TMEM55B Double Nickase Plasmid (h2) - sc-410227-NIC-2 from Santa Cruz Biotechnology
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TMEM55B CRISPR Activation Plasmid (h) - sc-410227-ACT from Santa Cruz Biotechnology
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TMEM55B CRISPR Activation Plasmid (h2) - sc-410227-ACT-2 from Santa Cruz Biotechnology
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TMEM55B Lentiviral Activation Particles (h) - sc-410227-LAC from Santa Cruz Biotechnology
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TMEM55B Lentiviral Activation Particles (h2) - sc-410227-LAC-2 from Santa Cruz Biotechnology
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TMEM55B siRNA (h) - sc-92328 from Santa Cruz Biotechnology
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TMEM55B shRNA Plasmid (h) - sc-92328-SH from Santa Cruz Biotechnology
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TMEM55B shRNA (h) Lentiviral Particles - sc-92328-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU038351 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0897 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0895 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP1128 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP1129 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0896 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP1127 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21644 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21644 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06014 from Sigma-Aldrich
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TMEM55B siRNA (Human) - CRJ3985 from Cohesion Biosciences
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TMEM55B - MBS8216725 from MyBioSource
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shRNA set against Human TMEM55B (NM_144568.2) - SHH430720 from Creative biogene
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shRNA set against Human TMEM55B(NM_144568.2) - SHL080400 from Creative biogene
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