| Gene Symbol |
Cfd
|
| Entrez Gene |
11537
|
| Alt Symbol |
Adn, DF
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
complement factor D (adipsin)
|
| Other Description |
28 kDa adipocyte protein|C3 convertase activator|D component (adipsin) of complement|adipsin|complement factor D|properdin factor D
|
| Swissprots |
P03953 Q61280
|
| Accessions |
AAA37262 CAA28378 CAA28379 EDL31632 EDL31633 EDL31634 EDL31635 P03953 AK143817 BAE25550 BC138778 AAI38779 BC138779 AAI38780 BC145412 AAI45413 BE136302 DV051476 M11768 AAA40486 NM_001291915 NP_001278844 NM_013459 NP_038487
|
| Function |
Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.
|
| Subcellular Location |
Secreted.
|
| Top Pathways |
Complement and coagulation cascades, Staphylococcus aureus infection
|