PPARGC1B
| Gene Symbol | PPARGC1B |
|---|---|
| Entrez Gene | 133522 |
| Alt Symbol | ERRL1, PERC, PGC-1(beta), PGC1B |
| Species | Human |
| Gene Type | protein-coding |
| Description | peroxisome proliferator-activated receptor gamma, coactivator 1 beta |
| Other Description | PGC-1-related estrogen receptor alpha coactivator|PPAR-gamma coactivator 1-beta|PPARGC-1-beta|peroxisome proliferator-activated receptor gamma coactivator 1-beta |
| Swissprots | Q8TDE5 B3KVW0 A2RUN0 Q86YN4 Q8TDE4 A2RUM8 Q86YN6 Q86YN3 Q8N1N9 Q86YN5 |
| Accessions | EAW61759 EAW61760 EAW61761 EAW61762 EAW61763 Q86YN6 AF468496 AAL78633 AF468497 AAL78634 AK024346 AK095391 BAC04541 AK123614 BAG53922 AK123715 AY188947 AAO40022 AY188948 AAO40023 AY188949 AAO40024 AY188950 AAO40025 BC026956 AAH26956 BC132971 AAI32972 BC132973 AAI32974 BC144251 AAI44252 BX648997 CA435617 XM_005268372 XP_005268429 XM_011537553 XP_011535855 XM_011537554 XP_011535856 XM_011537555 XP_011535857 XM_011537556 XP_011535858 XM_011537557 XP_011535859 NM_001172698 NP_001166169 NM_001172699 NP_001166170 NM_133263 NP_573570 |
| Function | Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcritional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. {ECO:0000269|PubMed:11854298, ECO:0000269|PubMed:12678921, ECO:0000269|PubMed:15546003, ECO:0000269|PubMed:23836911}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:11854298}. |
| Tissue Specificity | Ubiquitous with higher expression in heart, brain and skeletal muscle. {ECO:0000269|PubMed:11854298, ECO:0000269|PubMed:12678921}. |
PGC-1β CRISPR/Cas9 KO Plasmid (h) - sc-417930 from Santa Cruz Biotechnology
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PGC-1β HDR Plasmid (h) - sc-417930-HDR from Santa Cruz Biotechnology
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PGC-1β Double Nickase Plasmid (h) - sc-417930-NIC from Santa Cruz Biotechnology
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PGC-1β Double Nickase Plasmid (h2) - sc-417930-NIC-2 from Santa Cruz Biotechnology
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PGC-1β CRISPR Activation Plasmid (h) - sc-417930-ACT from Santa Cruz Biotechnology
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PGC-1β CRISPR Activation Plasmid (h2) - sc-417930-ACT-2 from Santa Cruz Biotechnology
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PGC-1β Lentiviral Activation Particles (h) - sc-417930-LAC from Santa Cruz Biotechnology
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PGC-1β Lentiviral Activation Particles (h2) - sc-417930-LAC-2 from Santa Cruz Biotechnology
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PGC-1β siRNA (h) - sc-62783 from Santa Cruz Biotechnology
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PGC-1β shRNA Plasmid (h) - sc-62783-SH from Santa Cruz Biotechnology
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PGC-1β shRNA (h) Lentiviral Particles - sc-62783-V from Santa Cruz Biotechnology
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PGC-1 beta RNAi - H00133522-R01 from Novus Biologicals
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MISSION® esiRNA - EHU151721 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17203 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17203 from Sigma-Aldrich
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PPARGC1B siRNA (Human) - CRJ5118 from Cohesion Biosciences
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shRNA set against Human PPARGC1B (NM_133263.3) - SHH380372 from Creative biogene
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shRNA set against Human PPARGC1B(NM_133263.3) - SHR108798 from Creative biogene
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Human PPARGC1B siRNA - orb275619 from Biorbyt
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PPARGC1B shRNA Plasmid (Human) - CHJ5118 from Cohesion Biosciences
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PPARGC1B miRNA 3'UTR clone - MiUTR1H-08135 from Creative biogene
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