Gene Symbol | Prdx6 |
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Entrez Gene | 11758 |
Alt Symbol | 1-Cys Prx, 1-cysPrx, 9430088D19Rik, AA690119, Aop2, Brp-12, CP-3, GPx, Ltw-4, Ltw4, Lvtw-4, NSGPx, ORF06, Prdx5, aiPLA2 |
Species | Mouse |
Gene Type | protein-coding |
Description | peroxiredoxin 6 |
Other Description | 1-Cys peroxiredoxin|acidic calcium-independent phospholipase A2|anti-oxidant protein 2, related sequence 3|antioxidant protein 2|non-selenium glutathione peroxidase|peroxiredoxin 5, related sequence 3|peroxiredoxin 6, related sequence 3|peroxiredoxin-6 |
Swissprots | Q91WT2 Q9QWW0 Q9QWP4 O08709 |
Accessions | AAC67553 AAD03716 AAP21829 O08709 AF004670 AAC53277 AF093852 AAC63376 AK030413 BAC26952 AK035097 AK076191 BAC36244 AK081980 AK157820 BAE34210 AK161710 BAE36544 AK168223 BAE40177 AK172888 BAD32166 BC013489 AAH13489 BC061181 AAH61181 Y12883 CAA73383 NM_001303408 NP_001290337 NM_007453 NP_031479 NR_130150 |
Function | Involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000250}. Lysosome {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Note=Also found in lung secretory organelles. {ECO:0000250}. |
Tissue Specificity | Highly expressed in heart, kidney and liver. Moderate expression in brain and stomach. Very low levels in intestine. |
Top Pathways | Phenylalanine metabolism |
PRX VI CRISPR/Cas9 KO Plasmid (m) - sc-419123 from Santa Cruz Biotechnology
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PRX VI HDR Plasmid (m) - sc-419123-HDR from Santa Cruz Biotechnology
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PRX VI Double Nickase Plasmid (m) - sc-419123-NIC from Santa Cruz Biotechnology
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PRX VI Double Nickase Plasmid (m2) - sc-419123-NIC-2 from Santa Cruz Biotechnology
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PRX VI CRISPR Activation Plasmid (m) - sc-419123-ACT from Santa Cruz Biotechnology
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PRX VI CRISPR Activation Plasmid (m2) - sc-419123-ACT-2 from Santa Cruz Biotechnology
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PRX VI Lentiviral Activation Particles (m) - sc-419123-LAC from Santa Cruz Biotechnology
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PRX VI Lentiviral Activation Particles (m2) - sc-419123-LAC-2 from Santa Cruz Biotechnology
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PRX VI siRNA (m) - sc-62897 from Santa Cruz Biotechnology
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PRX VI shRNA Plasmid (m) - sc-62897-SH from Santa Cruz Biotechnology
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PRX VI shRNA (m) Lentiviral Particles - sc-62897-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU073431 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN39269 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND39269 from Sigma-Aldrich
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PRDX6 siRNA (Mouse) - CRM0181 from Cohesion Biosciences
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shRNA set against Mouse PRDX6 (NM_007453.3) - SHH382364 from Creative biogene
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Mouse PRDX6 siRNA - orb279657 from Biorbyt
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PRDX6 shRNA Plasmid (Mouse) - CHM0181 from Cohesion Biosciences
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PRDX6 miRNA 3'UTR clone - MiUTR1M-09555 from Creative biogene
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