| Gene Symbol |
DPH7
|
| Entrez Gene |
92715
|
| Alt Symbol |
C9orf112, RRT2, WDR85
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
diphthamide biosynthesis 7
|
| Other Description |
WD repeat domain 85|WD repeat-containing protein 85|diphthamide biosynthesis protein 7|diphthine methyltransferase
|
| Swissprots |
Q96AB7 Q9BTV6
|
| Accessions |
CAF86364 CCQ43831 EAW88400 EAW88401 Q9BTV6 AJ420445 AK075115 BAC11411 AK094389 AK307180 AK308998 AK310226 AK310987 BC003123 AAH03123 BC016349 BC017335 AAH17335 BC040173 AAH40173 HQ448236 ADQ32716 XM_005266123 XP_005266180 XM_005266124 XP_005266181 XM_005266125 XP_005266182 XM_005266126 XP_005266183 XM_005266128 XP_005266185 XM_005266129 XP_005266186 XM_005266130 XP_005266187 XM_011519188 XP_011517490 XM_011519189 XP_011517491 XM_011519190 XP_011517492 XM_011519191 XP_011517493 XM_011519192 XP_011517494 XM_011519193 XP_011517495 XM_011519194 XP_011517496 XM_011519195 XP_011517497 XM_011519196 XP_011517498 XM_011519197 XP_011517499 XM_011519198 XP_011517500 XM_011519199 XP_011517501 XM_011519200 XP_011517502 NM_138778 NP_620133
|
| Function |
Catalyzes the demethylation of diphthine methyl ester to form diphthine, an intermediate diphthamide biosynthesis, a post- translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP- ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta). {ECO:0000250|UniProtKB:P38332, ECO:0000269|PubMed:19965467, ECO:0000269|PubMed:23486472}.
|