| Gene Symbol |
ELAVL1
|
| Entrez Gene |
1994
|
| Alt Symbol |
ELAV1, HUR, Hua, MelG
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ELAV like RNA binding protein 1
|
| Other Description |
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)|ELAV-like protein 1|Hu antigen R|embryonic lethal, abnormal vision, drosophila, homolog-like 1|hu-antigen R
|
| Swissprots |
Q9BTT1 Q53XN6 B4DVB8 Q15717
|
| Accessions |
CCA78939 EAW68949 EAW68950 Q15717 AI375368 AK022334 AK096659 AK301013 BAG62630 AL713686 AW139417 BC003376 AAH03376 BM664469 BM696191 BT009793 AAP88795 BU542524 BX647856 EU176230 ABW03681 EU176535 ABW03336 U38175 AAB41913 W37464 XM_011527777 XP_011526079 NM_001419 NP_001410
|
| Function |
RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability. Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation. Binds to poly-U elements and AU- rich elements (AREs) in the 3'-UTR of target mRNAs. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro. With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA. {ECO:0000269|PubMed:19029303}.
|
| Subcellular Location |
Cytoplasm. Nucleus. Note=Translocates into the cytoplasm following phosphorylation by MAPKAPK2.
|
| Tissue Specificity |
Ubiquitous.
|
| Top Pathways |
AMPK signaling pathway
|
![Western Blot: HuR/ELAVL1 Overexpression Lysate (Adult Normal) [NBL1-10224] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for HuR/ELAVL1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3026_HuR-ELAVL1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-10224-img0002.jpg)