PUS1

Gene Symbol PUS1
Entrez Gene 80324
Alt Symbol MLASA1
Species Human
Gene Type protein-coding
Description pseudouridylate synthase 1
Other Description mitochondrial tRNA pseudouridine synthase A|tRNA pseudouridine synthase A, mitochondrial|tRNA pseudouridine(38-40) synthase|tRNA pseudouridylate synthase I|tRNA uridine isomerase I|tRNA-uridine isomerase I
Swissprots Q9BU44 Q8WYT2 B3KQC1 A8K877 Q9Y606
Accessions ADP90494 ADP90495 ADP90496 ADP90497 ADP90498 ADP90499 ADP90500 ADP90501 ADP90502 ADP90503 ADP90504 ADP90505 ADP90506 ADP90507 ADP90508 ADP90509 ADP90510 ADP90511 ADP90512 ADP90513 ADP90514 ADP90515 ADP90516 ADP90517 ADP90518 ADP90519 ADP90520 ADP90521 ADP90522 ADP90523 ADP90524 ADP90525 ADP90526 ADP90527 ADP90528 ADP90529 ADP90530 ADP90531 ADP90532 ADP90533 ADP90534 ADP90535 ADP90536 ADP90537 ADP90538 ADP90539 ADP90540 ADP90541 ADP90542 ADP90543 ADP90544 ADP90545 ADP90546 ADP90547 ADP90548 ADP90549 ADP90550 ADP90551 ADP90552 ADP90553 ADP90554 ADP90555 ADP90556 ADP90557 ADP90558 ADP90559 ADP90560 ADP90561 ADP90562 ADP90563 ADP90564 ADP90565 ADP90566 ADP90567 ADP90568 ADP90569 ADP90570 ADP90571 ADP90572 ADP90573 CAF86716 EAW98530 EAW98531 EAW98532 EAW98533 Q9Y606 AF116238 AAD21042 AF318369 AAL55876 AI566545 AI884644 AK074659 BAG51983 AK292242 BAF84931 BC002901 AAH02901 BC009505 AAH09505 BC019320 AAH19320 BC035964 BG336824 BM923133 BX340929 CB118952 DQ892962 ABM83888 DQ896209 ABM87208 LK938829 XM_011538768 XP_011537070 XM_011538769 XP_011537071 XR_944737 NM_001002019 NP_001002019 NM_001002020 NP_001002020 NM_025215 NP_079491
Function Converts specific uridines to PSI in a number of tRNA substrates. Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA. Involved in regulation of nuclear receptor activity possibly through pseudouridylation of SRA1 RNA (By similarity). {ECO:0000250}.
Subcellular Location Isoform 1: Mitochondrion {ECO:0000269|PubMed:17056637}.
Tissue Specificity Widely expressed. High levels of expression found in brain and skeletal muscle. {ECO:0000269|PubMed:15108122}.

PUS1 (B-6) - sc-376443 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PUS1 (B-6): sc-376443. Western blot analysis of PUS1 expression in non-transfected: sc-117752 (A) and human PUS1 transfected: sc-172003 (B) 293T whole cell lysates.

PUS1 (C-4) - sc-376442 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PUS1 (C-4): sc-376442. Western blot analysis of PUS1 expression in non-transfected: sc-117752 (A) and human PUS1 transfected: sc-172003 (B) 293T whole cell lysates.

PUS1 (A-20) - sc-50664 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PUS1 (A-20): sc-50664. Western blot analysis of PUS1 expression in non-transfected: sc-117752 (A) and human PUS1 transfected: sc-172003 (B) 293T whole cell lysates.

PUS1 (E-3) - sc-376332 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PUS1 (E-3): sc-376332. Western blot analysis of PUS1 expression in non-transfected: sc-117752 (A) and human PUS1 transfected: sc-171271 (B) 293T whole cell lysates.

PUS1 (F-9) - sc-376331 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PUS1 (F-9): sc-376331. Western blot analysis of PUS1 expression in non-transfected: sc-117752 (A) and human PUS1 transfected: sc-171271 (B) 293T whole cell lysates.

PUS1 (H-280) - sc-292591 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PUS1 (H-280): sc-292591. Western blot analysis of PUS1 expression in A-431 (A), NCI-H460 (B) and Jurkat (C) whole cell lysates.

PUS1 (A-4) - sc-390043 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PUS1 (A-4): sc-390043. Western blot analysis of PUS1 expression in non-transfected 293T: sc-117752 (A), human PUS1 transfected 293T: sc-171271 (B) and HeLa (C) whole cell lysates.

PUS1 (D-20) - sc-50666 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PUS1 (D-20): sc-50666. Western blot analysis of PUS1 expression in non-transfected: sc-117752 (A) and mouse PUS1 transfected: sc-122846 (B) 293T whole cell lysates.

PUS1 (P-16) - sc-50667 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PUS1 (P-16): sc-50667. Western blot analysis of PUS1 expression in 293T whole cell lysate.

Anti-PUS1 antibody - ab155544 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-PUS1 antibody (ab155544) at 1/1000 dilution + A431 whole cell lysate at 30 µg

Anti-PUS1 antibody - ab85938 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human ovarian carcinoma tissue labelling PUS1 with ab85938 at 1/1000 (0.2µg/ml). Detection: DAB.

Anti-PUS1 antibody - ab84782 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab84782, at a 1/250 dilution, staining PUS1 in formalin fixed, paraffin embedded human breast carcinoma by Immunohistochemistry using DAB staining.

Anti-PUS1 antibody - ab169097 from Abcam

Prices $376.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
All lanes : Anti-PUS1 antibody (ab169097) at 1/500 dilutionLane 1 : PUS1-transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilutiondeveloped using the ECL technique

Anti-PUS1 antibody [EPR13235(B)] - ab175240 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR13235(B)
All lanes : Anti-PUS1 antibody [EPR13235(B)] (ab175240) at 1/1000 dilutionLane 1 : 293T lysateLane 2 : HeLa lysateLane 3 : Jurkat lysateLane 4 : Fetal brain lysateLysates/proteins at 10 µg per lane.

Anti-PUS1 Antibody (aa329-358, AP) - LS-C226994 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PUS1 Antibody (aa329-358, APC) - LS-C226995 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PUS1 Antibody (aa329-358, Biotin) - LS-C226996 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PUS1 Antibody (aa329-358, FITC) - LS-C226997 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PUS1 Antibody (aa329-358, Azide-free, HRP) - LS-C226998 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PUS1 Antibody (aa329-358, PE) - LS-C226999 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PUS1 Antibody (aa329-358) - LS-C324430 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PUS1 Antibody (C-Terminus) - LS-C30189 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Sp2/0 Cell Lysate

Anti-PUS1 Antibody (aa88-137) - LS-C145514 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PUS1 antibody LS-C145514 Western blot of Jurkat Cell lysate. Antibody concentration 1 ug/ml.

Anti-PUS1 Antibody (aa21-70) - LS-C116075 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
antibody LS-C116075 Western blot of Mouse Kidney lysate.

Anti-PUS1 Antibody (aa377-427) - LS-C288437 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human PUS1 by Immunohistochemistry. Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-PUS1 used at a dilution of 1:1000 (0.2 ug/ml). Detection: DAB.
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