| Gene Symbol | PTPN2 |
|---|---|
| Entrez Gene | 5771 |
| Alt Symbol | PTN2, PTPT, TC-PTP, TCELLPTP, TCPTP |
| Species | Human |
| Gene Type | protein-coding |
| Description | protein tyrosine phosphatase, non-receptor type 2 |
| Other Description | T-cell protein tyrosine phosphatase|tyrosine-protein phosphatase non-receptor type 2 |
| Swissprots | K7ENG3 A8K955 Q96HR2 A8MXU3 P17706 Q96AU5 |
| Accessions | ACA06062 ACA06063 ACA06064 EAX01532 EAX01533 EAX01534 EAX01535 EAX01536 EAX01537 EAX01538 EAX01539 P17706 AB209569 BAD92806 AK091525 AK225706 AK290649 BAF83338 AK292570 BAF85259 AW592324 BC008244 AAH08244 BC016727 AAH16727 BG699440 BQ010946 DB350067 HQ447463 ADQ31949 JF432521 ADZ15738 M25393 AAA65997 M80737 M81478 X93568 XM_005258124 XP_005258181 XM_005258125 XP_005258182 XM_005258127 XP_005258184 XM_011525705 XP_011524007 XM_011525706 XP_011524008 XM_011525707 XP_011524009 NM_001207013 NP_001193942 NM_001308287 NP_001295216 NM_002828 NP_002819 NM_080422 NP_536347 NM_080423 NP_536348 |
| Function | Non-receptor type tyrosine-specific phosphatase that dephosphorylates receptor protein tyrosine kinases including INSR, EGFR, CSF1R, PDGFR. Also dephosphorylates non-receptor protein tyrosine kinases like JAK1, JAK2, JAK3, Src family kinases, STAT1, STAT3, STAT5A, STAT5B and STAT6 either in the nucleus or the cytoplasm. Negatively regulates numerous signaling pathways and biological processes like hematopoiesis, inflammatory response, cell proliferation and differentiation, and glucose homeostasis. Plays a multifaceted and important role in the development of the immune system. Functions in T-cell receptor signaling through dephosphorylation of FYN and LCK to control T-cells differentiation and activation. Dephosphorylates CSF1R, negatively regulating its downstream signaling and macrophage differentiation. Negatively regulates cytokine (IL2/interleukin-2 and interferon)-mediated signaling through dephosphorylation of the cytoplasmic kinases JAK1, JAK3 and their substrate STAT1, that p |
| Subcellular Location | Isoform 1: Endoplasmic reticulum {ECO:0000269|PubMed:7593185}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000269|PubMed:7593185}. Note=Targeted to the endoplasmic reticulum by its C-terminal hydrophobic region. {ECO:0000269|PubMed:7593185}. |
| Tissue Specificity | Ubiquitously expressed. Isoform 2 is probably the major isoform. Isoform 1 is expressed in T-cells and in placenta. {ECO:0000269|PubMed:1731319, ECO:0000269|PubMed:2546150}. |