PTPN2

Gene Symbol	PTPN2
Entrez Gene	5771
Alt Symbol	PTN2, PTPT, TC-PTP, TCELLPTP, TCPTP
Species	Human
Gene Type	protein-coding
Description	protein tyrosine phosphatase, non-receptor type 2
Other Description	T-cell protein tyrosine phosphatase|tyrosine-protein phosphatase non-receptor type 2
Swissprots	K7ENG3 A8K955 Q96HR2 A8MXU3 P17706 Q96AU5
Accessions	ACA06062 ACA06063 ACA06064 EAX01532 EAX01533 EAX01534 EAX01535 EAX01536 EAX01537 EAX01538 EAX01539 P17706 AB209569 BAD92806 AK091525 AK225706 AK290649 BAF83338 AK292570 BAF85259 AW592324 BC008244 AAH08244 BC016727 AAH16727 BG699440 BQ010946 DB350067 HQ447463 ADQ31949 JF432521 ADZ15738 M25393 AAA65997 M80737 M81478 X93568 XM_005258124 XP_005258181 XM_005258125 XP_005258182 XM_005258127 XP_005258184 XM_011525705 XP_011524007 XM_011525706 XP_011524008 XM_011525707 XP_011524009 NM_001207013 NP_001193942 NM_001308287 NP_001295216 NM_002828 NP_002819 NM_080422 NP_536347 NM_080423 NP_536348
Function	Non-receptor type tyrosine-specific phosphatase that dephosphorylates receptor protein tyrosine kinases including INSR, EGFR, CSF1R, PDGFR. Also dephosphorylates non-receptor protein tyrosine kinases like JAK1, JAK2, JAK3, Src family kinases, STAT1, STAT3, STAT5A, STAT5B and STAT6 either in the nucleus or the cytoplasm. Negatively regulates numerous signaling pathways and biological processes like hematopoiesis, inflammatory response, cell proliferation and differentiation, and glucose homeostasis. Plays a multifaceted and important role in the development of the immune system. Functions in T-cell receptor signaling through dephosphorylation of FYN and LCK to control T-cells differentiation and activation. Dephosphorylates CSF1R, negatively regulating its downstream signaling and macrophage differentiation. Negatively regulates cytokine (IL2/interleukin-2 and interferon)-mediated signaling through dephosphorylation of the cytoplasmic kinases JAK1, JAK3 and their substrate STAT1, that p
Subcellular Location	Isoform 1: Endoplasmic reticulum {ECO:0000269|PubMed:7593185}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000269|PubMed:7593185}. Note=Targeted to the endoplasmic reticulum by its C-terminal hydrophobic region. {ECO:0000269|PubMed:7593185}.
Tissue Specificity	Ubiquitously expressed. Isoform 2 is probably the major isoform. Isoform 1 is expressed in T-cells and in placenta. {ECO:0000269|PubMed:1731319, ECO:0000269|PubMed:2546150}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human TCPTP full length protein - ab42575 from Abcam Category Protein Prices $284.00 Sizes 20 µg Source E. coli Species Human

Active human TCPTP protein fragment - ab187235 from Abcam Category Protein Prices $506.00 Sizes 5 µg Source E. coli Species Human

Human TCPTP peptide - ab14809 from Abcam Category Peptide

Human TCPTP peptide - ab14810 from Abcam Category Peptide

PTPN2 / TC-PTP Antibody Blocking Peptide - LS-E2347 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PTPN2 / TC-PTP Antibody Blocking Peptide - LS-E16589 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PTPN2 / TC-PTP Antibody Blocking Peptide - LS-E16590 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PTPN2 / TC-PTP Antibody Blocking Peptide - LS-E16591 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human TC-PTP/PTPN2 Protein - H00005771-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Source Wheat Germ Species Human

PTPN2-Antibody-C-term-Blocking-peptide - BP13311b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TCPTP-Antibody-C-term-K369-Blocking-Peptide - BP8431b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human TC-PTP (aa 2-314), CF - 1930-PT-050 from R&D Systems Category Protein Source E. coli-derived, Thr2-Asn314, with an N-terminal Met and 6-His tag

Human PTPN2 protein - orb139552 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Baculovirus-Insect Cells Species Human

PTPN2 enzyme - orb108364 from Biorbyt Category Protein Prices $553.00 Sizes 20 μg Species Human

PTPN2 Blocking Peptide - 33R-2730 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PTPN2 Blocking Peptide - 33R-4905 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PTPN2 Blocking Peptide - 33R-6310 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PTPN2 / TCPTP (2-315, Active Enzyme) - AR00170PU-N from Acris Antibodies Category Protein Prices $480.00 Sizes 20 µg Source E. coli Species Human

PTPN2 / TCPTP - H00005771-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

PTPN2 / TCPTP - H00005771-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

PTPN2 fusion protein - Ag1709 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

TC-PTP(PTPN2), Active Human Recombinant Protein - GWB-PSC876 from Genway Biotech Category Protein Prices $353.00 Sizes 20 µg Species Human

Recombinant Human PTPN2, His & GST tagged - PTPN2-940H from Creative Biomart Category Protein Source Baculovirus-Insect Cells Species Human

Recombinant Human PTPN2, Gly & Pro tagged - PTPN2-470H from Creative Biomart Category Protein Source Baculovirus-Insect cells Species Human

Recombinant Human PTPN2, GST-tagged - PTPN2-2056H from Creative Biomart Category Protein Source E.coli Species Human

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