Gene Symbol | Arpc2 |
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Entrez Gene | 76709 |
Alt Symbol | 2210023N03Rik, 34kDa, p34-Arc |
Species | Mouse |
Gene Type | protein-coding |
Description | actin related protein 2/3 complex, subunit 2 |
Other Description | actin-related protein 2/3 complex subunit 2|arp2/3 complex 34 kDa subunit |
Swissprots | Q3U870 Q9CVB6 |
Accessions | EDL00309 Q9CVB6 AK008777 BAB25889 AK037662 AK083263 AK151513 BAE30463 AK152356 BAE31148 AK170061 AK211266 AK213157 AV115645 BC099504 AAH99504 BC115750 AAI15751 BF016986 BY440113 XM_006496317 XP_006496380 NM_029711 NP_083987 |
Function | Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000269|PubMed:24153177}. |
Tissue Specificity | Expressed in hippocampal neurons (at protein level). {ECO:0000269|PubMed:24153177}. |
Top Pathways | Fc gamma R-mediated phagocytosis, Bacterial invasion of epithelial cells, Salmonella infection, Regulation of actin cytoskeleton |
p34-ARC CRISPR/Cas9 KO Plasmid (m) - sc-429398 from Santa Cruz Biotechnology
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p34-ARC HDR Plasmid (m) - sc-429398-HDR from Santa Cruz Biotechnology
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p34-ARC Double Nickase Plasmid (m) - sc-429398-NIC from Santa Cruz Biotechnology
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p34-ARC Double Nickase Plasmid (m2) - sc-429398-NIC-2 from Santa Cruz Biotechnology
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p34-ARC CRISPR Activation Plasmid (m) - sc-429398-ACT from Santa Cruz Biotechnology
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p34-ARC CRISPR Activation Plasmid (m2) - sc-429398-ACT-2 from Santa Cruz Biotechnology
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p34-ARC Lentiviral Activation Particles (m) - sc-429398-LAC from Santa Cruz Biotechnology
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p34-ARC Lentiviral Activation Particles (m2) - sc-429398-LAC-2 from Santa Cruz Biotechnology
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p34-ARC siRNA (m) - sc-155924 from Santa Cruz Biotechnology
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p34-ARC shRNA Plasmid (m) - sc-155924-SH from Santa Cruz Biotechnology
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p34-ARC shRNA (m) Lentiviral Particles - sc-155924-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU188691 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN27031 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND27031 from Sigma-Aldrich
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ARPC2 siRNA (Mouse) - CRM9692 from Cohesion Biosciences
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ARPC2 - MBS8233902 from MyBioSource
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shRNA set against Mouse ARPC2 (NM_029711.1) - SHH240634 from Creative biogene
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shRNA set against Mouse Arpc2(NM_029711.1) - SHG067919 from Creative biogene
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ARPC2 shRNA Plasmid (Mouse) - CHM9692 from Cohesion Biosciences
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ARPC2 miRNA 3'UTR clone - MiUTR1M-01698 from Creative biogene
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