| Gene Symbol |
HUWE1
|
| Entrez Gene |
10075
|
| Alt Symbol |
ARF-BP1, HECTH9, HSPC272, Ib772, LASU1, MULE, URE-B1, UREB1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
|
| Other Description |
ARF-binding protein 1|BJ-HCC-24 tumor antigen|E3 ubiquitin-protein ligase HUWE1|HECT domain protein LASU1|Mcl-1 ubiquitin ligase E3|URE-binding protein 1|homologous to E6AP carboxyl terminus homologous protein 9|large structure of UREB1|upstream regulatory element-binding protein 1
|
| Swissprots |
Q9NSL6 Q9HCJ4 Q6P4D0 Q4G2Z2 Q9P0A9 Q7Z6Z7 O15029 Q5H961 Q8NG67 Q9BUI0
|
| Accessions |
CAI39578 CAI39579 CAI39580 CAI39581 CAI42351 CAI42352 CAI42353 CAI42354 CAI42644 CAI42654 CAI42656 CAJ47378 CCQ43744 EAW93160 EAW93161 EAW93162 EAW93163 EAW93164 EAW93165 EAW93166 Q7Z6Z7 AB002310 BAA20771 AB071605 BAC06833 AF057569 AAC62492 AF161390 AAF28950 AK056671 AK091352 AK223167 BAD96887 AK294575 BAG57767 AL162050 CAB82393 AY772009 AAV90838 AY929612 AAX24125 BC002602 AAH02602 BC018750 AAH18750 BC038184 AAH38184 BC063505 AAH63505 BC072421 BC107576 AAI07577 BG334536 BU619074 CK002817 CR456813 CAG33094 DQ097177 AAY98258 R60532 XM_005261965 XP_005262022 XM_011530746 XP_011529048 XM_011530747 XP_011529049 XM_011530748 XP_011529050 XM_011530749 XP_011529051 XM_011530750 XP_011529052 XM_011530751 XP_011529053 XM_011530752 XP_011529054 XM_011530753 XP_011529055 XM_011530754 XP_011529056 XM_011530755 XP_011529057 XM_011530756 XP_011529058 XM_011530757 XP_011529059 XM_011530758 XP_011529060 XR_938360 NM_031407 NP_113584
|
| Function |
E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Binds to an upstream initiator-like sequence in the preprodynorphin gene. Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN. May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation. Mediates polyubiquitination of isoform 2 of PA2G4. {ECO:0000269|PubMed:15567145, ECO:0000269|PubMed:15767685, ECO:0000269|PubMed:15989956, ECO:0000269|PubMed:15989957, ECO:0000269|PubMed:17567951, ECO:0000269|PubMed:18488021, ECO:0000269|PubMed:19037095, ECO:000026
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:19713937}. Nucleus {ECO:0000269|PubMed:19713937}. Note=Mainly expressed in the cytoplasm of most tissues, except in the nucleus of spermatogonia, primary spermatocytes and neuronal cells (By similarity). Predominantly cytosolic or perinuclear in some colorectal carcinoma cells. {ECO:0000250|UniProtKB:Q7TMY8}.
|
| Tissue Specificity |
Weakly expressed in heart, brain and placenta but not in other tissues. Expressed in a number of cell lines, predominantly in those from colorectal carcinomas. {ECO:0000269|PubMed:15567145}.
|
| Top Pathways |
Ubiquitin mediated proteolysis
|