CUBN

Gene Symbol	CUBN
Entrez Gene	8029
Alt Symbol	IFCR, MGA1, gp280
Species	Human
Gene Type	protein-coding
Description	cubilin (intrinsic factor-cobalamin receptor)
Other Description	460 kDa receptor\|cubilin\|cubilin precursor variant 1\|cubilin precursor variant 2\|intestinal intrinsic factor receptor\|intrinsic factor-vitamin B12 receptor
Swissprots	Q5VTA6 O60494 B0YIZ4 Q96RU9
Accessions	AAK61829 AAK61830 ACA05973 ACA05974 EAW86221 O60494 AB209880 BAD93117 AF034611 AAC82612 AF086456 AK074536 BAG51968 AK075228 BAG52089 AK308290 AK309623 AK310404 BP270790 BP271329 XM_011519708 XP_011518010 XM_011519709 XP_011518011 XM_011519710 XP_011518012 XM_011519711 XP_011518013 NM_001081 NP_001072
Function	Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. Interaction with AMN controls its trafficking to the plasma membrane and facilitates endocytosis of ligands. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface. {ECO:0000269\|PubMed:10371504, ECO:0000269\|PubMed:11606717, ECO:0000269\|PubMed:11717447, ECO:0000269\|PubMed:14576052, ECO:0000269\|P
Subcellular Location	Endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Lysosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Colocalizes with AMN and LRP2 in the endocytotic apparatus of epithelial cells. {ECO:0000250}.
Tissue Specificity	Expressed in kidney proximal tubule cells, placenta, visceral yolk-sac cells and in absorptive intestinal cells. Expressed in the epithelium of intestine and kidney.
Top Pathways	Vitamin digestion and absorption

cubilin (H-300) - sc-50318 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

cubilin (T-16) - sc-23644 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

cubilin (T-16): sc-23644. Western blot analysis of cubilin expression in rat kidney tissue extract.

cubilin (Y-20) - sc-20607 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

cubilin (Y-20): sc-20607. Immunoperoxidase staining of formalin fixed, paraffin-embedded 7.5 dpc mouse embryo tissue showing apical membrane staining of extraembryonic visceral endoderm (low and high magnification). Kindly provided by Janet K. Chang, Center for Developmental Genetics, Stony Brook University.

Anti-Cubilin [EPR16259-27] antibody - C-terminal - ab191073 from Abcam

Prices	$357.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR16259-27

Anti-Cubilin [EPR16259-27] antibody - C-terminal (ab191073) at 1/50000 dilution + Human fetal kidney tissue lysate at 20 µgSecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-Cubilin antibody - ab65773 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-Cubilin antibody (ab65773) at 1 µg/ml + Kidney (Human) Tissue Lysate - adult normal tissue (ab30203) at 10 µgSecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutionPerformed under reducing conditions.

Anti-Cubilin antibody [EPR16259-34] - C-terminal - ab191074 from Abcam

Prices	$357.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR16259-34

Anti-Cubilin antibody [EPR16259-34] - C-terminal (ab191074) at 1/5000 dilution + Human fetal kidney lysate at 20 µgSecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-CUBN / Cubilin Antibody (aa3511-3623) - LS-C293574 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Western blot of recombinant CUBN / Cubilin.

Anti-CUBN / Cubilin Antibody (aa3157-3274) - LS-C293576 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CUBN / Cubilin Antibody (aa3157-3274) - LS-C293577 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CUBN / Cubilin Antibody (aa3157-3274) - LS-C293578 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CUBN / Cubilin Antibody (aa3157-3274, Biotin) - LS-C297096 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CUBN / Cubilin Antibody (aa3157-3274, Biotin) - LS-C297097 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CUBN / Cubilin Antibody (aa3511-3623, Biotin) - LS-C298394 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CUBN / Cubilin Antibody (aa3157-3274, Biotin) - LS-C299872 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CUBN / Cubilin Antibody (aa3511-3623, Biotin) - LS-C299873 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CUBN / Cubilin Antibody (aa3511-3623, FITC) - LS-C302030 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CUBN / Cubilin Antibody (aa3157-3274, FITC) - LS-C302029 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CUBN / Cubilin Antibody (aa3511-3623) - LS-C293579 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CUBN / Cubilin Antibody (aa3157-3274, FITC) - LS-C303852 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CUBN / Cubilin Antibody (aa3157-3274, FITC) - LS-C303853 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CUBN / Cubilin Antibody (aa3511-3623, FITC) - LS-C305087 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Cubilin Antibody [Unconjugated] - AF3700 from Novus Biologicals

Prices	$99.00, $359.00
Sizes	25 µg, 100 µg
Host	Sheep
Clonality	Polyclonal

Western blot shows lysates of human, mouse, and rat kidney tissue. PVDF membrane was probed with 1 µg/mL of Sheep Anti-Human/Mouse/Rat Cubilin Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3700) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # HAF016). A specific band was detected for Cubilin at approximately 500 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Cubilin Antibody [Biotin] - BAF3700 from Novus Biologicals

Prices	$390.00
Sizes	50 µg
Host	Sheep
Clonality	Polyclonal

Cubilin Polyclonal Antibody - bs-3901R from Bioss

Prices	$269.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

$Antigen: bs-3901P, 0.2ug/100ul \\nPrimary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000; \\nSecondary: HRP conjugated Goat-Anti-Rabbit IgG(bs-0295G-HRP) at 1: 5000;\\nTMB staining;\\nRead the data in MicroplateReader by 450$

Human/Mouse/Rat Cubilin Antibody - AF3700 from R&D Systems

Prices	$99.00, $359.00
Sizes	25 µg, 100 µg
Host	Sheep

Detection of Human, Mouse, and Rat Cubilin by Western Blot. Western blot shows lysates of human, mouse, and rat kidney tissue. PVDF membrane was probed with 1 µg/mL of Sheep Anti-Human/Mouse/ Rat Cubilin Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3700) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # HAF016 ). A specific band was detected for Cubilin at approximately 500 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1 .

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