CUBN

Gene Symbol CUBN
Entrez Gene 8029
Alt Symbol IFCR, MGA1, gp280
Species Human
Gene Type protein-coding
Description cubilin (intrinsic factor-cobalamin receptor)
Other Description 460 kDa receptor|cubilin|cubilin precursor variant 1|cubilin precursor variant 2|intestinal intrinsic factor receptor|intrinsic factor-vitamin B12 receptor
Swissprots Q5VTA6 O60494 B0YIZ4 Q96RU9
Accessions AAK61829 AAK61830 ACA05973 ACA05974 EAW86221 O60494 AB209880 BAD93117 AF034611 AAC82612 AF086456 AK074536 BAG51968 AK075228 BAG52089 AK308290 AK309623 AK310404 BP270790 BP271329 XM_011519708 XP_011518010 XM_011519709 XP_011518011 XM_011519710 XP_011518012 XM_011519711 XP_011518013 NM_001081 NP_001072
Function Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. Interaction with AMN controls its trafficking to the plasma membrane and facilitates endocytosis of ligands. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface. {ECO:0000269|PubMed:10371504, ECO:0000269|PubMed:11606717, ECO:0000269|PubMed:11717447, ECO:0000269|PubMed:14576052, ECO:0000269|P
Subcellular Location Endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Lysosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Colocalizes with AMN and LRP2 in the endocytotic apparatus of epithelial cells. {ECO:0000250}.
Tissue Specificity Expressed in kidney proximal tubule cells, placenta, visceral yolk-sac cells and in absorptive intestinal cells. Expressed in the epithelium of intestine and kidney.
Top Pathways Vitamin digestion and absorption

cubilin CRISPR/Cas9 KO Plasmid (h) - sc-402129 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

cubilin HDR Plasmid (h) - sc-402129-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

cubilin Double Nickase Plasmid (h) - sc-402129-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

cubilin Double Nickase Plasmid (h2) - sc-402129-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

cubilin CRISPR Activation Plasmid (h) - sc-402129-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

cubilin CRISPR Activation Plasmid (h2) - sc-402129-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

cubilin Lentiviral Activation Particles (h) - sc-402129-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

cubilin Lentiviral Activation Particles (h2) - sc-402129-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

cubilin siRNA (h) - sc-40099 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

cubilin shRNA Plasmid (h) - sc-40099-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

cubilin shRNA (h) Lentiviral Particles - sc-40099-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Cubilin RNAi - H00008029-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU110091 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN6769 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CUBN siRNA (Human) - CRH5345 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CUBN - MBS8238774 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human CUBN(NM_001081.3) - SHG211245 from Creative biogene

Category siRNA
Species Reactivities Human

CUBN shRNA Plasmid (Human) - CHH5345 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

CUBN miRNA 3'UTR clone - MiUTR1H-02550 from Creative biogene

Species Reactivities Human
Search more