| Gene Symbol | CUBN |
|---|---|
| Entrez Gene | 8029 |
| Alt Symbol | IFCR, MGA1, gp280 |
| Species | Human |
| Gene Type | protein-coding |
| Description | cubilin (intrinsic factor-cobalamin receptor) |
| Other Description | 460 kDa receptor|cubilin|cubilin precursor variant 1|cubilin precursor variant 2|intestinal intrinsic factor receptor|intrinsic factor-vitamin B12 receptor |
| Swissprots | Q5VTA6 O60494 B0YIZ4 Q96RU9 |
| Accessions | AAK61829 AAK61830 ACA05973 ACA05974 EAW86221 O60494 AB209880 BAD93117 AF034611 AAC82612 AF086456 AK074536 BAG51968 AK075228 BAG52089 AK308290 AK309623 AK310404 BP270790 BP271329 XM_011519708 XP_011518010 XM_011519709 XP_011518011 XM_011519710 XP_011518012 XM_011519711 XP_011518013 NM_001081 NP_001072 |
| Function | Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. Interaction with AMN controls its trafficking to the plasma membrane and facilitates endocytosis of ligands. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface. {ECO:0000269|PubMed:10371504, ECO:0000269|PubMed:11606717, ECO:0000269|PubMed:11717447, ECO:0000269|PubMed:14576052, ECO:0000269|P |
| Subcellular Location | Endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Lysosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Colocalizes with AMN and LRP2 in the endocytotic apparatus of epithelial cells. {ECO:0000250}. |
| Tissue Specificity | Expressed in kidney proximal tubule cells, placenta, visceral yolk-sac cells and in absorptive intestinal cells. Expressed in the epithelium of intestine and kidney. |
| Top Pathways | Vitamin digestion and absorption |