| Gene Symbol | CSNK1E |
|---|---|
| Entrez Gene | 1454 |
| Alt Symbol | CKIepsilon, HCKIE |
| Species | Human |
| Gene Type | protein-coding |
| Description | casein kinase 1, epsilon |
| Other Description | CKI-epsilon|CKIe|casein kinase I isoform epsilon |
| Swissprots | P49674 |
| Accessions | EAW60228 EAW60230 EAW60232 EAW60233 EAW60234 P49674 AB024597 BAA92345 AB091043 BAC10902 AK223498 BAD97218 BC006490 AAH06490 BC013088 BQ434269 BQ642398 BT019831 AAV38634 BU517079 CF594072 CR456429 CAG30315 CU012990 CAK54421 CU013278 CAK54720 DQ892612 ABM83538 DQ895852 ABM86778 L37043 AAC41761 NM_001894 NP_001885 NM_152221 NP_689407 |
| Function | Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phospohorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine- induced granuloytic differentiation. {ECO:0000269|PubMed:12556519, ECO:0000269|PubMed:15070676, ECO:0000269|PubMed:15917222, ECO:0000269|PubMed:16790549}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. |
| Tissue Specificity | Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. Expressed in monocytes and lymphocytes but not in granulocytes. |
| Top Pathways | Wnt signaling pathway, Hedgehog signaling pathway, Circadian rhythm, Hippo signaling pathway |