CSNK1E

Gene Symbol CSNK1E
Entrez Gene 1454
Alt Symbol CKIepsilon, HCKIE
Species Human
Gene Type protein-coding
Description casein kinase 1, epsilon
Other Description CKI-epsilon|CKIe|casein kinase I isoform epsilon
Swissprots P49674
Accessions EAW60228 EAW60230 EAW60232 EAW60233 EAW60234 P49674 AB024597 BAA92345 AB091043 BAC10902 AK223498 BAD97218 BC006490 AAH06490 BC013088 BQ434269 BQ642398 BT019831 AAV38634 BU517079 CF594072 CR456429 CAG30315 CU012990 CAK54421 CU013278 CAK54720 DQ892612 ABM83538 DQ895852 ABM86778 L37043 AAC41761 NM_001894 NP_001885 NM_152221 NP_689407
Function Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phospohorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine- induced granuloytic differentiation. {ECO:0000269|PubMed:12556519, ECO:0000269|PubMed:15070676, ECO:0000269|PubMed:15917222, ECO:0000269|PubMed:16790549}.
Subcellular Location Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Tissue Specificity Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. Expressed in monocytes and lymphocytes but not in granulocytes.
Top Pathways Wnt signaling pathway, Hedgehog signaling pathway, Circadian rhythm, Hippo signaling pathway

CK1ε Antibody - 12448 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from 293T cells, mock transfected (-) or transfected with constructs expressing Myc-tagged full-length human CK1δ (CK1δ-Myc/DDK; +) or Myc-tagged full-length human CK1ε (CK1ε-Myc/DDK; +), using CK1ε Antibody (upper) or Myc-Tag (71D10) Rabbit mAb #2278 (lower).

casein kinase Iε (C-20) - sc-6471 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
casein kinase Iε siRNA (h): sc-29914. Western blot analysis of casein kinase Iε expression in non-transfected control (A) and casein kinase Iε siRNA transfected (B) HeLa cells. Blot probed with casein kinase Iε (C-20): sc-6471. GAPDH (FL-335): sc-25778 used as specificity and loading control.

casein kinase Iε (H-60) - sc-25423 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
casein kinase Iε (H-60): sc-25423. Immunoperoxidase staining of formalin fixed, paraffin-embedded human urothelial cancer tissue showing cytoplasmic and nuclear staining of tumor cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

Anti-CK1 epsilon antibody - ab70110 from Abcam

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab70110 at 1/500 dilution staining CK1 epsilon in HeLa cells by Immunofluorescence, in the absence or presence of the immunising peptide.

Anti-CK1 epsilon antibody - ab133713 from Abcam

Prices $384.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human brain cortex neurons labelling CK1 epsilon with ab133713 at 15 µg/ml, followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-CK1 epsilon antibody - ab77336 from Abcam

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-CK1 epsilon antibody (ab77336) at 1 µg/ml + HEK293 cell lysate in RIPA buffer at 35 µg

Anti-CK1 epsilon antibody [AF6C1] - ab82426 from Abcam

Prices $384.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone AF6C1
Anti-CK1 epsilon antibody [AF6C1] (ab82426) at 1/1000 dilution + Human brain tissue lysate - whole at 50 µgSecondaryHRP-conjugated Goat anti-mouse IgG polyclonal at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-CK1 epsilon antibody - Carboxyterminal end - ab71687 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-CK1 epsilon antibody - Carboxyterminal end (ab71687) at 1/100 dilution + SKBR3 cell lysate at 12.5 µgSecondaryHRP anti rabbit

Anti-CK1 epsilon antibody - N-terminal - ab200815 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CSNK1E / CK1 Epsilon Antibody - LS-C331694 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using CSNK1E antibody.

Anti-CSNK1E / CK1 Epsilon Antibody (aa153-416, clone 5C9) - LS-C338879 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 5C9
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CSNK1E (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CSNK1E.

Anti-CSNK1E / CK1 Epsilon Antibody (aa153-416, clone 5H10) - LS-C338880 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 5H10
IHC of paraffin-embedded Human lymph node tissue using anti-CSNK1E mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).

Anti-CSNK1E / CK1 Epsilon Antibody (aa153-416, clone 5D4) - LS-C338878 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 5D4
IHC of paraffin-embedded Carcinoma of Human prostate tissue using anti-CSNK1E mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).

Anti-CSNK1E / CK1 Epsilon Antibody (C-Terminus) IHC-plus™ - LS-B2412 from LifeSpan Bioscience

Host Goat
Clonality Polyclonal
Anti-CSNK1E antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2412 concentration 5 ug/ml.

Anti-CSNK1E / CK1 Epsilon Antibody - LS-C77826 from LifeSpan Bioscience

Host Sheep
Clonality Polyclonal

Anti-CSNK1E / CK1 Epsilon Antibody (Biotin) - LS-C183139 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CSNK1E / CK1 Epsilon Antibody (FITC) - LS-C183140 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CSNK1E / CK1 Epsilon Antibody (HRP) - LS-C183141 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CSNK1E / CK1 Epsilon Antibody - LS-C189970 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CSNK1E / CK1 Epsilon Antibody - LS-C211140 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CSNK1E / CK1 Epsilon Antibody (HRP) - LS-C211141 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CSNK1E / CK1 Epsilon Antibody (Biotin) - LS-C211143 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CSNK1E / CK1 Epsilon Antibody (FITC) - LS-C211142 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CSNK1E / CK1 Epsilon Antibody (aa282-310, APC) - LS-C255549 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CSNK1E / CK1 Epsilon Antibody (aa282-310, AP) - LS-C255547 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
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