Gene Symbol | CSNK1E |
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Entrez Gene | 1454 |
Alt Symbol | CKIepsilon, HCKIE |
Species | Human |
Gene Type | protein-coding |
Description | casein kinase 1, epsilon |
Other Description | CKI-epsilon|CKIe|casein kinase I isoform epsilon |
Swissprots | P49674 |
Accessions | EAW60228 EAW60230 EAW60232 EAW60233 EAW60234 P49674 AB024597 BAA92345 AB091043 BAC10902 AK223498 BAD97218 BC006490 AAH06490 BC013088 BQ434269 BQ642398 BT019831 AAV38634 BU517079 CF594072 CR456429 CAG30315 CU012990 CAK54421 CU013278 CAK54720 DQ892612 ABM83538 DQ895852 ABM86778 L37043 AAC41761 NM_001894 NP_001885 NM_152221 NP_689407 |
Function | Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phospohorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine- induced granuloytic differentiation. {ECO:0000269|PubMed:12556519, ECO:0000269|PubMed:15070676, ECO:0000269|PubMed:15917222, ECO:0000269|PubMed:16790549}. |
Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. |
Tissue Specificity | Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. Expressed in monocytes and lymphocytes but not in granulocytes. |
Top Pathways | Wnt signaling pathway, Hedgehog signaling pathway, Circadian rhythm, Hippo signaling pathway |
Active human CK1 epsilon full length protein - ab104024 from Abcam
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CSNK1E / CK1 Epsilon Antibody Blocking Peptide - LS-E3514 from LifeSpan Bioscience
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CSNK1E / CK1 Epsilon Antibody Blocking Peptide - LS-E8927 from LifeSpan Bioscience
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CSNK1E / CK1 Epsilon Antibody Blocking Peptide - LS-E26325 from LifeSpan Bioscience
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CSNK1E / CK1 Epsilon Antibody Blocking Peptide - LS-E18659 from LifeSpan Bioscience
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Recombinant Human Casein Kinase 1 epsilon Protein - H00001454-Q01 from Novus Biologicals
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Casein Kinase 1 epsilon Recombinant Protein - H00001454-P01 from Novus Biologicals
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CSNK1E Peptide - P2490 from Novus Biologicals
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CSNK1E-Antibody-C-term-Blocking-peptide - BP7403a from Abgent, a WuXi AppTec company
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Casein Kinase 1 epsilon blocking peptide - GTX88851-PEP from GeneTex
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Recombinant human Casein kinase I isoform epsilon protein (OPCA00380) - OPCA00380 from Aviva Systems Biology
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Human CSNK1E protein - orb245802 from Biorbyt
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Human CSNK1E protein - orb244137 from Biorbyt
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Human CSNK1E protein - orb245073 from Biorbyt
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CSNK1E Immunizing peptide - orb16917 from Biorbyt
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CK1 epsilon Peptide - AC21-1160-P from Abcore
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Casein kinase I epsilon - H00001454-P01 from Acris Antibodies
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Casein kinase I epsilon - H00001454-Q01-10 from Acris Antibodies
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Casein kinase I epsilon - H00001454-Q01-25 from Acris Antibodies
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Casein kinase I epsilon - P5525 from Acris Antibodies
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CSNK1E Peptide - 45-437P from ProSci
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CSNK1E fusion protein - ag1742 from Proteintech Group
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Recombinant Human CSNK1E - CSNK1E-27754TH from Creative Biomart
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Recombinant Human CSNK1E, His-tagged - CSNK1E-27871TH from Creative Biomart
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Recombinant Human Casein Kinase 1, Epsilon, GST-tagged - CSNK1E-1007H from Creative Biomart
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