Gene Symbol | CC2D2A |
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Entrez Gene | 57545 |
Alt Symbol | JBTS9, MKS6 |
Species | Human |
Gene Type | protein-coding |
Description | coiled-coil and C2 domain containing 2A |
Other Description | coiled-coil and C2 domain-containing protein 2A |
Swissprots | E9PEV5 Q3SYP3 E7EP21 D6RB72 Q9H8A7 Q9P2K1 B3FW08 A6ND97 |
Accessions | CCQ43067 EAW92734 Q9P2K1 AA441801 AB037766 BAA92583 AB384183 BAG10039 AI376394 AK023876 BAB14710 AK025543 AK096047 AK309178 BC053865 BC061921 BC070395 BC103710 AAI03711 BX647334 CF528984 DA860072 DB043556 EU450799 ACC96081 N35522 XM_005248177 XP_005248234 XM_011513869 XP_011512171 XM_011513870 XP_011512172 XM_011513871 XP_011512173 XM_011513872 XP_011512174 XM_011513873 XP_011512175 XM_011513874 XP_011512176 NM_001080522 NP_001073991 NM_001164720 NP_001158192 NM_020785 NP_065836 |
Function | Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm. Cytoplasm, cytoskeleton, cilium basal body. Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme. {ECO:0000250}. |
Tissue Specificity | Strongly expressed in prostate, pancreas, kidney, lung, liver, retina, kidney, fetal brain and fetal kidney. Lower expression in spleen, small intestine, colon, skeletal muscle, ovary, thymus and heart. {ECO:0000269|PubMed:18387594, ECO:0000269|PubMed:18950740}. |
CC2D2A CRISPR/Cas9 KO Plasmid (h) - sc-412830 from Santa Cruz Biotechnology
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CC2D2A HDR Plasmid (h) - sc-412830-HDR from Santa Cruz Biotechnology
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CC2D2A Double Nickase Plasmid (h) - sc-412830-NIC from Santa Cruz Biotechnology
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CC2D2A Double Nickase Plasmid (h2) - sc-412830-NIC-2 from Santa Cruz Biotechnology
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CC2D2A CRISPR Activation Plasmid (h) - sc-412830-ACT from Santa Cruz Biotechnology
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CC2D2A CRISPR Activation Plasmid (h2) - sc-412830-ACT-2 from Santa Cruz Biotechnology
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CC2D2A Lentiviral Activation Particles (h) - sc-412830-LAC from Santa Cruz Biotechnology
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CC2D2A Lentiviral Activation Particles (h2) - sc-412830-LAC-2 from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU094461 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5437 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5437 from Sigma-Aldrich
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CC2D2A siRNA (Human) - CRJ1525 from Cohesion Biosciences
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CC2D2A - MBS8203541 from MyBioSource
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shRNA set against Human CC2D2A (NM_001080522.2) - SHH255629 from Creative biogene
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Human CC2D2A siRNA - orb272026 from Biorbyt
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CC2D2A shRNA Plasmid (Human) - CHJ1525 from Cohesion Biosciences
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CC2D2A miRNA 3'UTR clone - MiUTR3H-12252 from Creative biogene
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CC2D2A miRNA 3'UTR clone - MiUTR3H-12253 from Creative biogene
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CC2D2A miRNA 3'UTR clone - MiUTR3H-12254 from Creative biogene
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