| Gene Symbol | VPS26A |
|---|---|
| Entrez Gene | 9559 |
| Alt Symbol | HB58, Hbeta58, PEP8A, VPS26 |
| Species | Human |
| Gene Type | protein-coding |
| Description | vacuolar protein sorting 26 homolog A (S. pombe) |
| Other Description | vacuolar protein sorting-associated protein 26A|vesicle protein sorting 26A |
| Swissprots | O75436 Q9H982 B2RDD3 Q8TBH4 A8MZ56 |
| Accessions | EAW54311 EAW54312 EAW54313 O75436 AF054179 AAC39912 AF175266 AAF89954 AK022992 BAB14351 AK290536 BAF83225 AK297142 BAG59643 AK309021 AK315496 BAG37880 AL110166 BC022505 AAH22505 BQ048905 BX647725 BX649092 CD358963 EU832481 ACE87653 EU832561 ACE86963 XM_011540378 XP_011538680 NM_001035260 NP_001030337 NM_004896 NP_004887 |
| Function | Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins (Probable). The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (Probable). Required for retrograde transport of lysosomal enzyme re |
| Subcellular Location | Cytoplasm. Endosome membrane; Peripheral membrane protein. Early endosome {ECO:0000269|PubMed:15078903}. Note=Localizes to tubular profiles adjacent to endosomes (PubMed:15078903). Predominantly found in early not late endosomes (By similarity). {ECO:0000250|UniProtKB:P40336}. |