| Gene Symbol |
POLR2G
|
| Entrez Gene |
5436
|
| Alt Symbol |
RPB19, RPB7, hRPB19, hsRPB7
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
polymerase (RNA) II (DNA directed) polypeptide G
|
| Other Description |
DNA directed RNA polymerase II 19 kda polypeptide|DNA-directed RNA polymerase II 19 kDa polypeptide|DNA-directed RNA polymerase II subunit G|DNA-directed RNA polymerase II subunit RPB7|RNA polymerase II 19 kDa subunit|RNA polymerase II seventh subunit|RNA polymerase II subunit B7
|
| Swissprots |
B2R5C0 Q2M1Z4 P62487
|
| Accessions |
AAB96827 EAW74090 EAW74091 EAW74092 P62487 AK312131 BAG35067 AW016747 BC112162 AAI12163 BC112164 AAI12165 BG530809 U20659 AAA86500 NM_002696 NP_002687
|
| Function |
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA (By similarity). Binds RNA. {ECO:0000250, ECO:0000269|PubMed:9852112}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:9852112}.
|
| Top Pathways |
Huntington's disease, Epstein-Barr virus infection, Purine metabolism, RNA polymerase, Pyrimidine metabolism
|