Gene Symbol | EVC2 |
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Entrez Gene | 132884 |
Alt Symbol | LBN |
Species | Human |
Gene Type | protein-coding |
Description | Ellis van Creveld syndrome 2 |
Other Description | ellis-van Creveld syndrome protein 2|limbin |
Swissprots | Q86YT3 Q8NG49 Q86YT4 Q86UK5 |
Accessions | AAY41034 AAY41048 AIV00554 EAW82412 EAW82413 EAW82414 Q86UK5 AB083067 BAC06590 AW137166 AY152402 AAN86577 AY152403 AAN86578 AY185210 AAO22066 BC111455 AAI11456 BC143836 BG755658 XM_011513392 XP_011511694 XM_011513393 XP_011511695 XM_011513394 XP_011511696 NM_001166136 NP_001159608 NM_147127 NP_667338 |
Function | Positive regulator of the hedgehog signaling pathway (By similarity). Plays a critical role in bone formation and skeletal development. {ECO:0000250}. |
Subcellular Location | Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250}. Cell projection, cilium {ECO:0000250}. Cell projection, cilium membrane {ECO:0000250}. Nucleus {ECO:0000250}. |
Tissue Specificity | Found in the heart, placenta, lung, liver, skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:12468274}. |
EVC2 CRISPR/Cas9 KO Plasmid (h) - sc-407502 from Santa Cruz Biotechnology
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EVC2 HDR Plasmid (h) - sc-407502-HDR from Santa Cruz Biotechnology
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EVC2 Double Nickase Plasmid (h) - sc-407502-NIC from Santa Cruz Biotechnology
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EVC2 Double Nickase Plasmid (h2) - sc-407502-NIC-2 from Santa Cruz Biotechnology
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EVC2 CRISPR Activation Plasmid (h) - sc-407502-ACT from Santa Cruz Biotechnology
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EVC2 CRISPR Activation Plasmid (h2) - sc-407502-ACT-2 from Santa Cruz Biotechnology
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EVC2 Lentiviral Activation Particles (h) - sc-407502-LAC from Santa Cruz Biotechnology
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EVC2 Lentiviral Activation Particles (h2) - sc-407502-LAC-2 from Santa Cruz Biotechnology
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EVC2 siRNA (h) - sc-105339 from Santa Cruz Biotechnology
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EVC2 shRNA Plasmid (h) - sc-105339-SH from Santa Cruz Biotechnology
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EVC2 shRNA (h) Lentiviral Particles - sc-105339-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU152681 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN8018 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8018 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03335 from Sigma-Aldrich
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EVC2 siRNA (Human) - CRJ5103 from Cohesion Biosciences
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EVC2 - MBS8214889 from MyBioSource
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shRNA set against Human Evc2 (NM_147127.4) - SHH287769 from Creative biogene
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Human EVC2 siRNA - orb275604 from Biorbyt
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EVC2 shRNA Plasmid (Human) - CHJ5103 from Cohesion Biosciences
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EVC2 miRNA 3'UTR clone - MiUTR3H-09090 from Creative biogene
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EVC2 miRNA 3'UTR clone - MiUTR3H-09091 from Creative biogene
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