ETHE1

Gene Symbol ETHE1
Entrez Gene 23474
Alt Symbol HSCO, YF13H12
Species Human
Gene Type protein-coding
Description ethylmalonic encephalopathy 1
Other Description ethylmalonic encephalopathy protein 1|hepatoma subtracted clone one protein|persulfide dioxygenase ETHE1, mitochondrial|protein ETHE1, mitochondrial|sulfur dioxygenase ETHE1
Swissprots Q96HR0 Q9H001 O95571
Accessions AAG09063 EAW57195 EAW57196 EAW57197 O95571 AI879202 AK309880 AK315346 BAG37744 AM392804 CAL37682 BC008250 AAH08250 D83198 BAA34595 XM_005258687 XP_005258744 XM_005258688 XP_005258745 XM_011526685 XP_011524987 NM_014297 NP_055112
Function Sulfur dioxygenase that plays an essential role in hydrogen sulfide catabolism in the mitochondrial matrix. Hydrogen sulfide (H(2)S) is first oxidized by SQRDL, giving rise to cysteine persulfide residues. ETHE1 consumes molecular oxygen to catalyze the oxidation of the persulfide, once it has been transferred to a thiophilic acceptor, such as glutathione (R-SSH). Plays an important role in metabolic homeostasis in mitochondria by metabolizing hydrogen sulfide and preventing the accumulation of supraphysiological H(2)S levels that have toxic effects, due to the inhibition of cytochrome c oxidase. First described as a protein that can shuttle between the nucleus and the cytoplasm and suppress p53-induced apoptosis by sequestering the transcription factor RELA/NFKB3 in the cytoplasm and preventing its accumulation in the nucleus (PubMed:12398897). {ECO:0000269|PubMed:12398897, ECO:0000269|PubMed:14732903, ECO:0000269|PubMed:19136963, ECO:0000269|PubMed:23144459}.
Subcellular Location Cytoplasm. Nucleus. Mitochondrion matrix. Note=According to PubMed:12398897, it is cytoplasmic and nuclear. According to PubMed:14732903, it is found in the mitochondrial matrix.
Tissue Specificity Ubiquitously expressed. {ECO:0000269|PubMed:14732903}.
Top Pathways Sulfur metabolism

ETHE1 (B-12) - sc-393869 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ETHE1 (B-12): sc-393869. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic, nuclear and nucleolar localization.

ETHE1 (T-17) - sc-161565 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ETHE1 (T-17): sc-161565. Western blot analysis of ETHE1 expression in non-transfected: sc-117752 (A) and human ETHE1 transfected: sc-110987 (B) 293T whole cell lysates.

ETHE1 (Y-13) - sc-161566 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ETHE1 (Y-13): sc-161566. Western blot analysis of ETHE1 expression in non-transfected 293T: sc-117752 (A), human ETHE1 transfected 293T: sc-110987 (B), Jurkat (C), SW480 (D) and HeLa (E) whole cell lysates.

Anti-ETHE1 antibody - ab154041 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-ETHE1 antibody (ab154041) at 1/1000 dilution + HCT116 whole cell lysate at 30 µg

Anti-ETHE1 antibody - ab67528 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Immunofluorescence analysis of HeLa cells using protein A purified ab76528 at 10 ug/ml

Anti-ETHE1 antibody - ab126166 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-ETHE1 antibody (ab126166) at 1/5000 dilution + HepG2 whole cell lysate at 30 µg

Anti-ETHE1 antibody - ab108138 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-ETHE1 antibody (ab108138) at 1 µg/ml + COLO205 cell lysate at 10 µg

Anti-ETHE1 antibody [EPR11697] - ab174302 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR11697
All lanes : Anti-HPS1 antibody [EP8429(2)] (ab174301) at 1/1000 dilutionLane 1 : HepG2 cell lysateLane 2 : HeLa cell lysateLane 3 : SW480 cell lysateLane 4 : Jurkat cell lysateLysates/proteins at 10 µg per lane.

Anti-ETHE1 antibody - C-terminal - ab135589 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-ETHE1 antibody - C-terminal (ab135589) + mouse liver tissue lysates at 35 µg

Anti-ETHE1 Antibody - LS-C307437 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-ETHE1 Antibody (aa92-141) - LS-C117062 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ETHE1 antibody LS-C117062 Western blot of COLO205 cell lysate.

Anti-ETHE1 Antibody (aa180-209) IHC-plus™ - LS-B10538 from LifeSpan Bioscience

Prices $395.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Anti-ETHE1 antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B10538 dilution 1:100.

Anti-ETHE1 Antibody (aa103-130) - LS-C98379 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
ETHE1 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human colon carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.

ETHE1 Antibody - NBP2-16385 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: ETHE1 Antibody [NBP2-16385] - Sample (50 ug of whole cell lysate) A: Mouse Liver, 12% SDS PAGE gel, diluted at 1:1000.

ETHE1 Antibody - NBP1-81689 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: ETHE1 Antibody [NBP1-81689] - Lane 1: NIH-3T3 cell lysate (Mouse embryonic fibroblast cells). Lane 2: NBT-II cell lysate (Rat Wistar bladder tumor cells).

ETHE1 Antibody - H00023474-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

ETHE1 Antibody - NBP1-81690 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: ETHE1 Antibody [NBP1-81690] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11. Lane 2: Human cell line RT-193

ETHE1 Antibody - NBP1-81688 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: ETHE1 Antibody [NBP1-81688] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Negative control (vector only transfected HEK293T lysate). Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).

ETHE1 Antibody - NBP2-16384 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: ETHE1 Antibody [NBP2-16384] - A. 30 ug Jurkat whole cell lysate/extract B. 30 ug Raji whole cell lysate/extract 15 % SDS-PAGE ETHE1 antibody dilution: 1:500

ETHE1 Polyclonal Antibody - bs-7610R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ETHE1 (6-19) antibody produced in rabbit - SAB1101592 from Sigma-Aldrich

Prices $328.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-ETHE1 (6-19) (RB): <B>Cat. No. SAB1101592</B>: Immunofluorescence of HUVEC cells using Anti-ETHE1 (6-19) (RB) at a 1:50 dilution, taken at 40× magnification and nuclear staining with Hoescht 33342 (blue). Yale HTCB IF procedure used. Images may have been adjusted to improve viewing quality. If you would like the original image, please send a request to protocols@sial.com

Anti-ETHE1 (201-215) antibody produced in rabbit - SAB1101593 from Sigma-Aldrich

Prices $328.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-ETHE1 (201-215) (RB): <B>Cat. No. SAB1101593</B>: Immunofluorescence of HUVEC cells using Anti-ETHE1 (201-215) (RB) at a 1:50 dilution, taken at 40× magnification and nuclear staining with Hoescht 33342 (blue). Yale HTCB IF procedure used. Images may have been adjusted to improve viewing quality. If you would like the original image, please send a request to protocols@sial.com

Anti-ETHE1 antibody produced in mouse - SAB1400456 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Polyclonal Anti-ETHE1, antibody produced in mouse, purified immunoglobulin: <B>Cat. No. SAB1400456</B>: Antibody concentration: 3.0 μg/mL using human human small Intestine tissue.

Anti-ETHE1 antibody produced in rabbit - HPA028360 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-ETHE1: <B>Cat. No. HPA028360</B>: Immunohistochemical staining of human rectum shows strong cytoplasmic positivity(granular pattern) in glandular cells.

Anti-ETHE1 antibody produced in rabbit - HPA029029 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-ETHE1: <B>Cat. No. HPA029029</B>: Immunohistochemical staining of human rectum shows strong cytoplasmic positivity in glandular cells.
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