ETHE1

Gene Symbol	ETHE1
Entrez Gene	23474
Alt Symbol	HSCO, YF13H12
Species	Human
Gene Type	protein-coding
Description	ethylmalonic encephalopathy 1
Other Description	ethylmalonic encephalopathy protein 1|hepatoma subtracted clone one protein|persulfide dioxygenase ETHE1, mitochondrial|protein ETHE1, mitochondrial|sulfur dioxygenase ETHE1
Swissprots	Q96HR0 Q9H001 O95571
Accessions	AAG09063 EAW57195 EAW57196 EAW57197 O95571 AI879202 AK309880 AK315346 BAG37744 AM392804 CAL37682 BC008250 AAH08250 D83198 BAA34595 XM_005258687 XP_005258744 XM_005258688 XP_005258745 XM_011526685 XP_011524987 NM_014297 NP_055112
Function	Sulfur dioxygenase that plays an essential role in hydrogen sulfide catabolism in the mitochondrial matrix. Hydrogen sulfide (H(2)S) is first oxidized by SQRDL, giving rise to cysteine persulfide residues. ETHE1 consumes molecular oxygen to catalyze the oxidation of the persulfide, once it has been transferred to a thiophilic acceptor, such as glutathione (R-SSH). Plays an important role in metabolic homeostasis in mitochondria by metabolizing hydrogen sulfide and preventing the accumulation of supraphysiological H(2)S levels that have toxic effects, due to the inhibition of cytochrome c oxidase. First described as a protein that can shuttle between the nucleus and the cytoplasm and suppress p53-induced apoptosis by sequestering the transcription factor RELA/NFKB3 in the cytoplasm and preventing its accumulation in the nucleus (PubMed:12398897). {ECO:0000269|PubMed:12398897, ECO:0000269|PubMed:14732903, ECO:0000269|PubMed:19136963, ECO:0000269|PubMed:23144459}.
Subcellular Location	Cytoplasm. Nucleus. Mitochondrion matrix. Note=According to PubMed:12398897, it is cytoplasmic and nuclear. According to PubMed:14732903, it is found in the mitochondrial matrix.
Tissue Specificity	Ubiquitously expressed. {ECO:0000269|PubMed:14732903}.
Top Pathways	Sulfur metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ETHE1 full length protein - ab119454 from Abcam Category Protein Source E. coli Species Human

ETHE1 Antibody Blocking Peptide - LS-E8348 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ETHE1 Antibody Blocking Peptide - LS-E8349 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ETHE1 Antibody Blocking Peptide - LS-E19849 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ETHE1 Partial Recombinant Protein - H00023474-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

ETHE1 Recombinant Protein - H00023474-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

ETHE1 Protein - NBP1-78881 from Novus Biologicals Category Protein Prices $369.00 Sizes 100 µg Species Human

ETHE1-Antibody-Center-Blocking-Peptide - BP6641c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ETHE1-Antibody-C-term-Blocking-Peptide - BP6641b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human ETHE1 protein (His Tag) - orb138834 from Biorbyt Category Protein Prices $323.00, $646.00 Sizes 20 μg, 100 μg Source E. coli Species Human

Human ETHE1 protein - orb168316 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E.coli

ETHE1 Blocking Peptide - 33R-8197 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

ETHE1 protein (His tag) - 80R-2124 from Fitzgerald Category Protein Prices $365.00 Sizes 100 µg Source E.coli

ETHE1 / HSCO (13-254, His-tag) - AR50207PU-N from Acris Antibodies Category Protein Prices $1,010.00 Sizes 500 µg Source E. coli Species Human

ETHE1 / HSCO (13-254, His-tag) - AR50207PU-S from Acris Antibodies Category Protein Prices $410.00 Sizes 100 µg Source E. coli Species Human

ETHE1 / HSCO - H00023474-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

ETHE1 / HSCO - H00023474-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

ETHE1 / HSCO - H00023474-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

ETHE1 / HSCO - H00023474-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Ethylmalonic Encephalopathy 1, Human Recombinant - 228-12849-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Species Human

Recombinant Human Ethylmalonic Encephalopathy 1 - 228-12849-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source E.coli. Species Human

Recombinant Human Ethylmalonic Encephalopathy 1 - 228-12849-3 from RayBiotech Category Protein Source E.coli. Species Human

ETHE1, 13-254aa, Human, His tag, E.coli - 01-P1382 from ARP American Research Products Category Protein Prices $189.00, $449.00, $1,089.00 Sizes 20 µg, 50 µg, 500 µg Species Human

ETHE1 Human - PRPS-1034 from NeoScientific Category Protein Prices $65.00, $169.00, $4,680.00 Sizes 5 µg, 20 µg, 1 mg Source E.coli. Species Human

Recombinant Human Ethylmalonic Encephalopathy 1 Protein - BP002879-PRO-1027 from Syd Labs Category Protein Prices $160.00, $3,600.00 Sizes 20 µg, 1 mg Source E. coli-derived. Species Human

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