| Gene Symbol |
ZFP42
|
| Entrez Gene |
132625
|
| Alt Symbol |
REX-1, REX1, ZNF754, zfp-42
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ZFP42 zinc finger protein
|
| Other Description |
REX1 transcription factor|reduced expression protein 1|zinc finger protein 42 homolog|zinc finger protein 754
|
| Swissprots |
D3DP65 Q96MM3 Q8WXE2
|
| Accessions |
CAD33430 EAX04610 EAX04611 EAX04612 Q96MM3 AA641545 AF450454 AAL47167 AK056719 BAB71264 AY429593 AAR07993 BC160056 AAI60056 BE301754 CN420210 XM_011531604 XP_011529906 XM_011531605 XP_011529907 XM_011531606 XP_011529908 XM_011531607 XP_011529909 NM_001304358 NP_001291287 NM_174900 NP_777560
|
| Function |
Involved in the reprogramming of X-chromosome inactivation during the acquisition of pluripotency. Required for efficient elongation of TSIX, a non-coding RNA antisense to XIST. Binds DXPas34 enhancer within the TSIX promoter. Involved in ES cell self-renewal (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000250}.
|
| Tissue Specificity |
Expressed in kidney, epidermal keratinocytes, prostate epithelial cells, bronchial and small airway lung epithelial cells (at protein level). Expressed in malignant kidney and several carcinoma cell lines (at protein level). Expressed in embryonic stem cells, kidney, epidermal keratinocytes, prostate epithelial cells, bronchial and small airway lung epithelial cells. Expressed in embryonal carcinomas, seminomas, malignant kidney and several carcinoma cell lines. {ECO:0000269|PubMed:12110702, ECO:0000269|PubMed:16344273, ECO:0000269|PubMed:16424014, ECO:0000269|PubMed:16865673}.
|
![Western Blot: Rex1 Overexpression Lysate (Adult Normal) [NBP2-05092] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Rex1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5798_Rex1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-05092-img0001.jpg)