| Gene Symbol | DEPDC5 |
|---|---|
| Entrez Gene | 9681 |
| Alt Symbol | DEP.5, FFEVF |
| Species | Human |
| Gene Type | protein-coding |
| Description | DEP domain containing 5 |
| Other Description | DEP domain-containing protein 5 |
| Swissprots | O75140 A6H8V6 Q5THZ1 B9EGN9 Q5THZ0 A8MPX9 Q9UGV8 Q6MZX3 Q68DR1 Q6PEZ1 Q5THZ3 Q9UH13 B4DH93 Q5K3V5 Q5THY9 |
| Accessions | AAD08635 EAW59996 EAW59997 EAW59998 EAW59999 O75140 AB014545 BAA31620 AJ698950 CAG27889 AJ698951 CAG27890 AJ704764 CAG28924 AK294583 BAG57774 AK294987 BAG58054 AK299886 BAG61733 AK300737 BAH13337 AK309008 AK316364 BAH14735 BC057797 AAH57797 BC136612 AAI36613 BC144291 BC146766 AAI46767 BM145115 BP354669 BX640828 CAE45904 CA310381 CR749304 CAH18159 DA339804 DB381506 XM_005261862 XP_005261919 XM_011530557 XP_011528859 XM_011530558 XP_011528860 XM_011530559 XP_011528861 XM_011530560 XP_011528862 XM_011530561 XP_011528863 XM_011530562 XP_011528864 XM_011530563 XP_011528865 XM_011530564 XP_011528866 XM_011530565 XP_011528867 XM_011530566 XP_011528868 XM_011530567 XP_011528869 XM_011530568 XP_011528870 XM_011530569 XP_011528871 XR_937972 XR_937973 NM_001007188 NP_001007189 NM_001136029 NP_001129501 NM_001242896 NP_001229825 NM_001242897 NP_001229826 NM_014662 NP_055477 NR_110988 |
| Function | As a component of the GATOR1 complex, inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC- containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. {ECO:0000269|PubMed:23723238}. |
| Subcellular Location | Cytoplasm, cytosol {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. |
| Tissue Specificity | Expressed in developing and adult brain. {ECO:0000269|PubMed:23542701}. |
DEPDC5 CRISPR/Cas9 KO Plasmid (h) - sc-402806 from Santa Cruz Biotechnology
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DEPDC5 HDR Plasmid (h) - sc-402806-HDR from Santa Cruz Biotechnology
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DEPDC5 Double Nickase Plasmid (h) - sc-402806-NIC from Santa Cruz Biotechnology
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DEPDC5 Double Nickase Plasmid (h2) - sc-402806-NIC-2 from Santa Cruz Biotechnology
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DEPDC5 CRISPR Activation Plasmid (h) - sc-402806-ACT from Santa Cruz Biotechnology
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DEPDC5 CRISPR Activation Plasmid (h2) - sc-402806-ACT-2 from Santa Cruz Biotechnology
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DEPDC5 Lentiviral Activation Particles (h) - sc-402806-LAC from Santa Cruz Biotechnology
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DEPDC5 Lentiviral Activation Particles (h2) - sc-402806-LAC-2 from Santa Cruz Biotechnology
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DEPDC5 siRNA (h) - sc-77132 from Santa Cruz Biotechnology
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DEPDC5 shRNA Plasmid (h) - sc-77132-SH from Santa Cruz Biotechnology
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DEPDC5 shRNA (h) Lentiviral Particles - sc-77132-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU008331 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7151 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7151 from Sigma-Aldrich
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DEPDC5 siRNA (Human) - CRH6453 from Cohesion Biosciences
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DEPDC5 - MBS8215436 from MyBioSource
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shRNA set against Human Depdc5 (NM_014662.3) - SHH277165 from Creative biogene
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DEPDC5 shRNA Plasmid (Human) - CHH6453 from Cohesion Biosciences
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DEPDC5 miRNA 3'UTR clone - MiUTR3H-13166 from Creative biogene
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DEPDC5 miRNA 3'UTR clone - MiUTR3H-13167 from Creative biogene
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DEPDC5 miRNA 3'UTR clone - MiUTR3H-13168 from Creative biogene
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