Gene Symbol | IFIT2 |
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Entrez Gene | 3433 |
Alt Symbol | G10P2, GARG-39, IFI-54, IFI-54K, IFI54, IFIT-2, ISG-54 K, ISG-54K, ISG54, P54, cig42 |
Species | Human |
Gene Type | protein-coding |
Description | interferon-induced protein with tetratricopeptide repeats 2 |
Other Description | Interferon, alpha-inducible protein (MW 54kD)|interferon-induced 54 kDa protein|interferon-induced protein 54 |
Swissprots | P09913 Q5T767 |
Accessions | AAA59191 CAA30438 EAW50145 P09913 AA143609 AA765174 AF026944 AK300431 BAG62157 AK312831 BC005987 AAH05987 BC032839 AAH32839 DA631671 EB387611 NM_001547 NP_001538 |
Function | IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O- methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis. {ECO:0000269|PubMed:21190939}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:21190939}. Endoplasmic reticulum {ECO:0000269|PubMed:21190939}. |
IFIT2 (C-20) - sc-82640 from Santa Cruz Biotechnology
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IFIT2 (E-15) - sc-82641 from Santa Cruz Biotechnology
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IFIT2 (F-12) - sc-390724 from Santa Cruz Biotechnology
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IFIT2 (H-150) - sc-367014 from Santa Cruz Biotechnology
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Anti-IFIT2 antibody - ab55837 from Abcam
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Anti-IFIT2 antibody - ab113112 from Abcam
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Anti-IFIT2 antibody - ab168407 from Abcam
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Anti-IFIT2 antibody - ab83892 from Abcam
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Anti-IFIT2 antibody - ab111965 from Abcam
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Anti-IFIT2 antibody - ab138724 from Abcam
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Anti-IFIT2 antibody - N-terminal - ab154487 from Abcam
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Anti-ISG54 / IFIT2 Antibody (aa307-335, AP) - LS-C259910 from LifeSpan Bioscience
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Anti-ISG54 / IFIT2 Antibody (aa307-335, APC) - LS-C259911 from LifeSpan Bioscience
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Anti-ISG54 / IFIT2 Antibody (aa307-335, Biotin) - LS-C259912 from LifeSpan Bioscience
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Anti-ISG54 / IFIT2 Antibody (aa307-335, FITC) - LS-C259913 from LifeSpan Bioscience
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Anti-ISG54 / IFIT2 Antibody (aa307-335, Azide-free, HRP) - LS-C259914 from LifeSpan Bioscience
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Anti-ISG54 / IFIT2 Antibody (aa307-335, PE) - LS-C259915 from LifeSpan Bioscience
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Anti-ISG54 / IFIT2 Antibody (aa306-335) - LS-C322153 from LifeSpan Bioscience
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Anti-ISG54 / IFIT2 Antibody - LS-C308386 from LifeSpan Bioscience
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Anti-ISG54 / IFIT2 Antibody - LS-C310702 from LifeSpan Bioscience
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Anti-ISG54 / IFIT2 Antibody (N-Terminus) - LS-C101940 from LifeSpan Bioscience
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Anti-ISG54 / IFIT2 Antibody (aa307-335) - LS-C165124 from LifeSpan Bioscience
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Anti-ISG54 / IFIT2 Antibody (aa100-321) - LS-C178590 from LifeSpan Bioscience
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IFIT2 Antibody - NBP2-15180 from Novus Biologicals
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IFIT2 Antibody - NBP1-31164 from Novus Biologicals
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