Gene Symbol | ARHGAP44 |
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Entrez Gene | 9912 |
Alt Symbol | NPC-A-10, RICH2 |
Species | Human |
Gene Type | protein-coding |
Description | Rho GTPase activating protein 44 |
Other Description | RICH-2|Rho-type GTPase-activating protein RICH2|RhoGAP interacting with CIP4 homologs protein 2|rho GTPase-activating protein 44|rho GTPase-activating protein RICH2 |
Swissprots | Q9Y4Q4 A6NCP5 O75160 A8MQB2 Q7Z5Z7 Q17R89 |
Accessions | EAW89965 EAW89966 EAW89967 EAW89968 EAW89969 Q17R89 AB014572 BAA31647 AK023797 AK294538 BAG57745 AL080100 CAH10728 AL096728 CAB46376 AY320403 AAP73805 BC022452 AAH22452 BC070074 BC094754 BC117412 AAI17413 BC117416 AAI17417 BC143852 BC143853 AAI43854 BC143855 BC143856 BM993036 DA403021 DB461035 XM_005256888 XP_005256945 XM_005256889 XP_005256946 XM_005256890 XP_005256947 XM_005256891 XP_005256948 XM_006721615 XP_006721678 NM_014859 NP_055674 |
Function | GTPase-activating protein (GAP) that stimulates the GTPase activity of Rho-type GTPases. Thereby, controls Rho-type GTPases cycling between their active GTP-bound and inactive GDP- bound states. May act as a GAP for CDC42 and RAC1. Endosomal recycling protein which, in association with SHANK3, is involved in synaptic plasticity. Promotes GRIA1 exocytosis from recycling endosomes and spine morphological changes associated to long-term potentiation. {ECO:0000269|PubMed:11431473}. |
Subcellular Location | Cell projection, dendritic spine {ECO:0000250}. Recycling endosome {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=In CA1 hippocampal synapses, detected at both presynaptic and postsynaptic sites. {ECO:0000250}. |
Tissue Specificity | Highly expressed in brain. Expressed at weak level in other tissues. {ECO:0000269|PubMed:11431473}. |
RICH2 CRISPR/Cas9 KO Plasmid (h) - sc-406654 from Santa Cruz Biotechnology
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RICH2 HDR Plasmid (h) - sc-406654-HDR from Santa Cruz Biotechnology
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RICH2 Double Nickase Plasmid (h) - sc-406654-NIC from Santa Cruz Biotechnology
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RICH2 Double Nickase Plasmid (h2) - sc-406654-NIC-2 from Santa Cruz Biotechnology
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RICH2 CRISPR Activation Plasmid (h) - sc-406654-ACT from Santa Cruz Biotechnology
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RICH2 CRISPR Activation Plasmid (h2) - sc-406654-ACT-2 from Santa Cruz Biotechnology
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RICH2 Lentiviral Activation Particles (h) - sc-406654-LAC from Santa Cruz Biotechnology
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RICH2 Lentiviral Activation Particles (h2) - sc-406654-LAC-2 from Santa Cruz Biotechnology
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RICH2 siRNA (h) - sc-94119 from Santa Cruz Biotechnology
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RICH2 shRNA Plasmid (h) - sc-94119-SH from Santa Cruz Biotechnology
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RICH2 shRNA (h) Lentiviral Particles - sc-94119-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU075451 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3433 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3433 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09335 from Sigma-Aldrich
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ARHGAP44 siRNA (Human) - CRH6658 from Cohesion Biosciences
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ARHGAP44 - MBS8205013 from MyBioSource
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shRNA set against Human ARHGAP44 (NM_014859.4) - SHH239586 from Creative biogene
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Human ARHGAP44 siRNA - orb267160 from Biorbyt
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ARHGAP44 shRNA Plasmid (Human) - CHH6658 from Cohesion Biosciences
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ARHGAP44 miRNA 3'UTR clone - MiUTR1H-05223 from Creative biogene
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