LLGL1

Gene Symbol	LLGL1
Entrez Gene	3996
Alt Symbol	DLG4, HUGL, HUGL-1, HUGL1, LLGL
Species	Human
Gene Type	protein-coding
Description	lethal giant larvae homolog 1 (Drosophila)
Other Description	human homolog to the D-lgl gene protein|lethal(2) giant larvae protein homolog 1
Swissprots	Q58F11 O00188 A7MBM7 Q15334 Q86UK6
Accessions	EAW55657 EAW55658 EAW55659 EAW55660 Q15334 BC028037 AAH28037 BC028214 AAH28214 BC051466 BC151838 AAI51839 BC167831 AAI67831 BQ923585 BQ937224 D50550 BAA19516 X86371 CAA60130 XM_011523849 XP_011522151 XM_011523850 XP_011522152 XM_011523851 XP_011522153 XM_011523852 XP_011522154 XM_011523853 XP_011522155 XM_011523854 XP_011522156 XM_011523855 XP_011522157 XM_011523856 XP_011522158 NM_004140 NP_004131
Function	Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane. {ECO:0000269|PubMed:15735678, ECO:0000269|PubMed:16170365}.
Subcellular Location	Early endosome membrane {ECO:0000250}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}. Cell projection, axon {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12725730, ECO:0000269|PubMed:7542763}. Note=Localized to the lateral membrane during the polarization and formation cell-cell contacts. Enriched in developping axons (By similarity). {ECO:0000250}.
Tissue Specificity	Expressed in brain, kidney, and muscle but is barely seen in heart and placenta. Down-regulated or lost in all cell lines and in most of the tumor samples analyzed. Loss was associated with advanced stage of the disease. {ECO:0000269|PubMed:15735678, ECO:0000269|PubMed:16170365, ECO:0000269|PubMed:7542763}.
Top Pathways	Tight junction, Hippo signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

LLGL1 (D2B5A) Rabbit mAb - 12159 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone D2B5A

Hugl-1 (B-6) - sc-136993 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Hugl-1 (D-17) - sc-49991 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Hugl-1 (G-16) - sc-49992 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Hugl-1 (A-2) - sc-136992 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Hugl-1 (H-126) - sc-67243 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Hugl-1 (M-102) - sc-67244 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Hugl-1 (C-15) - sc-49990 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-Lgl1 antibody - ab39292 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Lgl1 antibody - ab194346 from Abcam Prices $370.00 Sizes 50 µl Host Mouse Clonality Polyclonal

Anti-Lgl1 antibody - N-terminal - ab135767 from Abcam Prices $359.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-LLGL1 / HUGL Antibody (phospho-Ser650/Ser654, Biotin) - LS-C278972 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-LLGL1 / HUGL Antibody (phospho-Ser650/Ser654, FITC) - LS-C278973 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-LLGL1 / HUGL Antibody (phospho-Ser650/Ser654, APC) - LS-C278971 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-LLGL1 / HUGL Antibody (phospho-Ser650/Ser654, AP) - LS-C278970 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-LLGL1 / HUGL Antibody (phospho-Ser650/Ser654, PE) - LS-C278975 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-LLGL1 / HUGL Antibody (phospho-Ser650/Ser654, Azide-free, HRP) - LS-C278974 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-LLGL1 / HUGL Antibody (phospho-Ser654) - LS-C330509 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-LLGL1 / HUGL Antibody (clone 5G2) - LS-C197620 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 5G2

Anti-LLGL1 / HUGL Antibody (phospho-Ser645 & 649) - LS-C99645 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-LLGL1 / HUGL Antibody (aa172-205) - LS-C99643 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

pan MAGUK Antibody (S28-86) - NBP1-48306 from Novus Biologicals Prices $379.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S28-86

Lgl1 Antibody (5G2) - H00003996-M01 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 5G2

Lgl1 Antibody - NBP1-84077 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Lgl1 Antibody - NBP1-84078 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

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