LLGL1

Gene Symbol	LLGL1
Entrez Gene	3996
Alt Symbol	DLG4, HUGL, HUGL-1, HUGL1, LLGL
Species	Human
Gene Type	protein-coding
Description	lethal giant larvae homolog 1 (Drosophila)
Other Description	human homolog to the D-lgl gene protein|lethal(2) giant larvae protein homolog 1
Swissprots	Q58F11 O00188 A7MBM7 Q15334 Q86UK6
Accessions	EAW55657 EAW55658 EAW55659 EAW55660 Q15334 BC028037 AAH28037 BC028214 AAH28214 BC051466 BC151838 AAI51839 BC167831 AAI67831 BQ923585 BQ937224 D50550 BAA19516 X86371 CAA60130 XM_011523849 XP_011522151 XM_011523850 XP_011522152 XM_011523851 XP_011522153 XM_011523852 XP_011522154 XM_011523853 XP_011522155 XM_011523854 XP_011522156 XM_011523855 XP_011522157 XM_011523856 XP_011522158 NM_004140 NP_004131
Function	Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane. {ECO:0000269|PubMed:15735678, ECO:0000269|PubMed:16170365}.
Subcellular Location	Early endosome membrane {ECO:0000250}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}. Cell projection, axon {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12725730, ECO:0000269|PubMed:7542763}. Note=Localized to the lateral membrane during the polarization and formation cell-cell contacts. Enriched in developping axons (By similarity). {ECO:0000250}.
Tissue Specificity	Expressed in brain, kidney, and muscle but is barely seen in heart and placenta. Down-regulated or lost in all cell lines and in most of the tumor samples analyzed. Loss was associated with advanced stage of the disease. {ECO:0000269|PubMed:15735678, ECO:0000269|PubMed:16170365, ECO:0000269|PubMed:7542763}.
Top Pathways	Tight junction, Hippo signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Lgl1 peptide - ab39291 from Abcam Category Peptide

Human Lgl1 protein fragment - ab114953 from Abcam Category Protein Source Wheat germ Species Human

DLG4 / PSD95 Antibody Blocking Peptide - LS-E18429 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DLG4 / PSD95 Antibody Blocking Peptide - LS-E27041 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

LLGL1 / HUGL Antibody Blocking Peptide - LS-E6930 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

LLGL1 / HUGL Antibody Blocking Peptide - LS-E6931 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PSD-95 Protein - H00001742-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human PSD-95 Protein - H00001742-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Lgl1 Partial Recombinant Protein - H00003996-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Lgl1 Peptide - P1023 from Novus Biologicals Category Peptide Species Human

Lgl1 Peptide - P1022 from Novus Biologicals Category Peptide Species Human

Lgl1 Peptide - P1024 from Novus Biologicals Category Peptide Species Human

LLGL1-Antibody-C-term-Blocking-Peptide - BP2197b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

LLGL1-Antibody-N-term-Blocking-Peptide - BP2197a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PSD95 blocking peptide - GTX88388-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat, Bovine

DLG4 Blocking Peptide - 33R-1027 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

LLGL1 - H00003996-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

LLGL1 - H00003996-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

LLGL1 fusion protein - ag18057 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

LLGL1 fusion protein - ag19066 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human LLGL1 - LLGL1-28095TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human Lethal(2) giant larvae protein homolog 1(LLGL1) ,partial - CSB-YP622993HU CSB-EP622993HU CSB-BP622993HU CSB-MP622993HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Lgl1 Recombinant Protein Antigen - NBP1-84078PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Lgl1 Recombinant Protein Antigen - NBP1-84077PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

PSD-95 Recombinant Protein Antigen - NBP1-80875PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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