Gene Symbol | GUCA2B |
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Entrez Gene | 2981 |
Alt Symbol | GCAP-II, UGN |
Species | Human |
Gene Type | protein-coding |
Description | guanylate cyclase activator 2B (uroguanylin) |
Other Description | guanylate cyclase activator 2B|prepro-uroguanylin|uroguanylin |
Swissprots | Q16661 Q52LV0 |
Accessions | AAC51729 CAA94311 EAX07169 Q16661 BC069301 AAH69301 BC093779 AAH93779 BC093781 AAH93781 U34279 AAC50416 Z50753 CAA90629 NM_007102 NP_009033 |
Function | Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport. |
Subcellular Location | Secreted. |
Tissue Specificity | Stomach and intestine. |
Uroguanylin CRISPR/Cas9 KO Plasmid (h) - sc-404519 from Santa Cruz Biotechnology
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Uroguanylin HDR Plasmid (h) - sc-404519-HDR from Santa Cruz Biotechnology
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Uroguanylin Double Nickase Plasmid (h) - sc-404519-NIC from Santa Cruz Biotechnology
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Uroguanylin Double Nickase Plasmid (h2) - sc-404519-NIC-2 from Santa Cruz Biotechnology
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Uroguanylin CRISPR Activation Plasmid (h) - sc-404519-ACT from Santa Cruz Biotechnology
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Uroguanylin CRISPR Activation Plasmid (h2) - sc-404519-ACT-2 from Santa Cruz Biotechnology
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Uroguanylin Lentiviral Activation Particles (h) - sc-404519-LAC from Santa Cruz Biotechnology
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Uroguanylin Lentiviral Activation Particles (h2) - sc-404519-LAC-2 from Santa Cruz Biotechnology
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Uroguanylin siRNA (h) - sc-44592 from Santa Cruz Biotechnology
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Uroguanylin shRNA Plasmid (h) - sc-44592-SH from Santa Cruz Biotechnology
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Uroguanylin shRNA (h) Lentiviral Particles - sc-44592-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU155471 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9797 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9797 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01225 from Sigma-Aldrich
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GUCA2B siRNA (Human) - CRH2020 from Cohesion Biosciences
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GUCA2B - MBS8229843 from MyBioSource
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shRNA set against Human Guca2b (NM_007102.2) - SHH309310 from Creative biogene
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Human GUCA2B siRNA - orb262522 from Biorbyt
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GUCA2B shRNA Plasmid (Human) - CHH2020 from Cohesion Biosciences
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GUCA2B miRNA 3'UTR clone - MiUTR4H-TG11386 from Creative biogene
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