| Gene Symbol |
RAB8B
|
| Entrez Gene |
51762
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
RAB8B, member RAS oncogene family
|
| Other Description |
RAB-8b protein|ras-related protein Rab-8B
|
| Swissprots |
Q5JPC4 Q92930 Q9P293
|
| Accessions |
EAW77641 EAW77642 Q92930 AB038995 BAA92249 AK001111 BAG50856 AK095444 BAG53055 AK297598 BAG59983 AL133607 AL833365 CAI46143 BC020654 AAH20654 BG721755 HQ447792 ADQ32276 U66624 AAC51199 XM_006720569 XP_006720632 XM_011521669 XP_011519971 NM_016530 NP_057614
|
| Function |
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may be involved in polarized vesicular trafficking and neurotransmitter release. May participate in cell junction dynamics in Sertoli cells (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:21255211}. Cytoplasmic vesicle, phagosome membrane {ECO:0000269|PubMed:21255211}; Lipid- anchor {ECO:0000269|PubMed:21255211}; Cytoplasmic side {ECO:0000269|PubMed:21255211}. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis.
|