Gene Symbol | RAB8B |
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Entrez Gene | 51762 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | RAB8B, member RAS oncogene family |
Other Description | RAB-8b protein|ras-related protein Rab-8B |
Swissprots | Q5JPC4 Q92930 Q9P293 |
Accessions | EAW77641 EAW77642 Q92930 AB038995 BAA92249 AK001111 BAG50856 AK095444 BAG53055 AK297598 BAG59983 AL133607 AL833365 CAI46143 BC020654 AAH20654 BG721755 HQ447792 ADQ32276 U66624 AAC51199 XM_006720569 XP_006720632 XM_011521669 XP_011519971 NM_016530 NP_057614 |
Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may be involved in polarized vesicular trafficking and neurotransmitter release. May participate in cell junction dynamics in Sertoli cells (By similarity). {ECO:0000250}. |
Subcellular Location | Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:21255211}. Cytoplasmic vesicle, phagosome membrane {ECO:0000269|PubMed:21255211}; Lipid- anchor {ECO:0000269|PubMed:21255211}; Cytoplasmic side {ECO:0000269|PubMed:21255211}. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis. |
Rab 8B CRISPR/Cas9 KO Plasmid (h) - sc-408887 from Santa Cruz Biotechnology
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Rab 8B HDR Plasmid (h) - sc-408887-HDR from Santa Cruz Biotechnology
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Rab 8B Double Nickase Plasmid (h) - sc-408887-NIC from Santa Cruz Biotechnology
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Rab 8B Double Nickase Plasmid (h2) - sc-408887-NIC-2 from Santa Cruz Biotechnology
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Rab 8B CRISPR Activation Plasmid (h) - sc-408887-ACT from Santa Cruz Biotechnology
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Rab 8B CRISPR Activation Plasmid (h2) - sc-408887-ACT-2 from Santa Cruz Biotechnology
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Rab 8B Lentiviral Activation Particles (h) - sc-408887-LAC from Santa Cruz Biotechnology
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Rab 8B Lentiviral Activation Particles (h2) - sc-408887-LAC-2 from Santa Cruz Biotechnology
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Rab 8B siRNA (h) - sc-106474 from Santa Cruz Biotechnology
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Rab 8B shRNA Plasmid (h) - sc-106474-SH from Santa Cruz Biotechnology
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Rab 8B shRNA (h) Lentiviral Particles - sc-106474-V from Santa Cruz Biotechnology
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RAB8B RNAi - H00051762-R01 from Novus Biologicals
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MISSION® esiRNA - EHU000791 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17868 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17868 from Sigma-Aldrich
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RAB8B siRNA (Human) - CRH9939 from Cohesion Biosciences
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RAB8B - MBS8226369 from MyBioSource
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shRNA set against Human RAB8B (NM_016530.2) - SHH388612 from Creative biogene
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shRNA set against Human RAB8B(NM_016530.2) - SHR160206 from Creative biogene
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RAB8B shRNA Plasmid (Human) - CHH9939 from Cohesion Biosciences
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RAB8B miRNA 3'UTR clone - MiUTR1H-08577 from Creative biogene
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